Bulletin of Materials Science

, Volume 29, Issue 6, pp 581–586

Towards a versatile platform based on magnetic nanoparticles for in vivo applications

  • E Duguet
  • S Vasseur
  • S Mornet
  • G Goglio
  • A Demourgues
  • J Portier
  • F Grasset
  • P Veverka
  • E Pollert
Article

DOI: 10.1007/s12034-006-0007-0

Cite this article as:
Duguet, E., Vasseur, S., Mornet, S. et al. Bull Mater Sci (2006) 29: 581. doi:10.1007/s12034-006-0007-0

Abstract

Magnetic nanoparticles have attracted wide attention because of their usefulness as contrast agents for magnetic resonance imaging (MRI) or colloidal mediators for cancer magnetic hyperthermia. This paper examines these in vivo applications through an understanding of the problems involved and the current and future possibilities for resolving them. A special emphasis is made on magnetic nanoparticle requirements from a physical viewpoint, the factors affecting their biodistribution and the solutions envisaged for enhancing their half-life in the blood compartment and targeting tumour cells. Then, our synthesis strategies are presented and focused on covalent platforms based on maghemite and dextran and capable to be tailorderivatized by surface molecular chemistry. The opportunity of taking advantage of temperature-dependence of magnetic properties of some complex oxides for controlling the in vivo temperature is also discussed.

Keywords

Magnetic nanoparticle surface functionalization in vivo biodistribution magnetic resonance imaging (MRI) magnetic hyperthermia contrast agent 

Copyright information

© Indian Academy of Sciences 2006

Authors and Affiliations

  • E Duguet
    • 1
  • S Vasseur
    • 1
  • S Mornet
    • 1
  • G Goglio
    • 1
  • A Demourgues
    • 1
  • J Portier
    • 1
  • F Grasset
    • 1
  • P Veverka
    • 2
  • E Pollert
    • 3
  1. 1.Institut de Chimie de la Matière Condensée de Bordeaux, UPR CNRS 9048Universite Bordeaux-1Pessac CedexFrance
  2. 2.Verres et Céramiques, UMR CNRS 6512Université de Rennes-1, Institut de Chimie de RennesRennes CedexFrance
  3. 3.Institute of PhysicsASCRPraha 6Czech Republic

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