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Molecular Biotechnology

, Volume 60, Issue 2, pp 169–183 | Cite as

Specialized Plant Metabolism Characteristics and Impact on Target Molecule Biotechnological Production

  • Hélio Nitta Matsuura
  • Sonia Malik
  • Fernanda de Costa
  • Morteza Yousefzadi
  • Mohammad Hossein Mirjalili
  • Randolph Arroo
  • Avninder S. Bhambra
  • Miroslav Strnad
  • Mercedes Bonfill
  • Arthur Germano Fett-NetoEmail author
Review

Abstract

Plant secondary metabolism evolved in the context of highly organized and differentiated cells and tissues, featuring massive chemical complexity operating under tight environmental, developmental and genetic control. Biotechnological demand for natural products has been continuously increasing because of their significant value and new applications, mainly as pharmaceuticals. Aseptic production systems of plant secondary metabolites have improved considerably, constituting an attractive tool for increased, stable and large-scale supply of valuable molecules. Surprisingly, to date, only a few examples including taxol, shikonin, berberine and artemisinin have emerged as success cases of commercial production using this strategy. The present review focuses on the main characteristics of plant specialized metabolism and their implications for current strategies used to produce secondary compounds in axenic cultivation systems. The search for consonance between plant secondary metabolism unique features and various in vitro culture systems, including cell, tissue, organ, and engineered cultures, as well as heterologous expression in microbial platforms, is discussed. Data to date strongly suggest that attaining full potential of these biotechnology production strategies requires being able to take advantage of plant specialized metabolism singularities for improved target molecule yields and for bypassing inherent difficulties in its rational manipulation.

Keywords

Genetically engineered cultures In vitro culture Natural products Secondary metabolites Synthetic biology 

Notes

Acknowledgements

Preparation of this manuscript was supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq, Brazil (AGFN) (Grant No. 306079/2013-5), and Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão - FAPEMA, Brazil (10/2015 BEPP).

Author’s Contribution

AGFN and SM conceived, outlined the review, and did most of the writing. HNM and FDC assisted in compiling literature data, drafting late versions of the manuscript and making figures. MY, MHM, RA, ASB, MS, and MB collected and helped analyzing the literature, and participated in drafting of the text.

Compliance with Ethical Standards

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

12033_2017_56_MOESM1_ESM.doc (28 kb)
Supplementary material 1 (DOC 28 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Hélio Nitta Matsuura
    • 1
  • Sonia Malik
    • 2
  • Fernanda de Costa
    • 1
  • Morteza Yousefzadi
    • 3
  • Mohammad Hossein Mirjalili
    • 4
  • Randolph Arroo
    • 5
  • Avninder S. Bhambra
    • 5
  • Miroslav Strnad
    • 6
  • Mercedes Bonfill
    • 7
  • Arthur Germano Fett-Neto
    • 1
    Email author
  1. 1.Plant Physiology Laboratory, Center for Biotechnology and Department of BotanyUFRGSPorto AlegreBrazil
  2. 2.Health Sciences Graduate Program, Biological and Health Sciences CenterFederal University of MaranhãoSão LuísBrazil
  3. 3.Department of Marine Biology, Faculty of Marine Sciences and TechnologyHormozgan UniversityBandar AbbasIran
  4. 4.Department of Agriculture, Medicinal Plants and Drugs Research InstituteShahid Beheshti UniversityTehranIran
  5. 5.Faculty of Health and Life SciencesDe Montfort UniversityLeicesterUK
  6. 6.Laboratory of Growth Regulators, Institute of Experimental Botany AS CRPalacký UniversityOlomoucCzech Republic
  7. 7.Plant Physiology Laboratory, Faculty of PharmacyUniversity of BarcelonaBarcelonaSpain

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