Advertisement

Medical Oncology

, 36:44 | Cite as

Prospective assessment of taste impairment and nausea during radiotherapy for head and neck cancer

  • Stefania Martini
  • Giuseppe Carlo Iorio
  • Francesca Arcadipane
  • Francesco Olivero
  • Patrick Silvetti
  • Monica Rampino
  • Paolo Garzino Demo
  • Massimo Fasolis
  • Giancarlo Pecorari
  • Mario Airoldi
  • Umberto Ricardi
  • Pierfrancesco FrancoEmail author
Original Paper
  • 33 Downloads

Abstract

Dysgeusia and nausea are common side effects observed in head and neck cancer patients treated with either exclusive radiotherapy or combined modality treatment. The aim of the present study was to prospectively evaluate dysgeusia, during treatment and follow-up, using the chemotherapy-induced taste alteration scale (CiTAS), a metrics based on 18-items exploring three dimensions (quantitative and qualitative changes in taste perception, and diet-related issues) identified through a four-factor analysis: decline in basic taste, discomfort, phantogeusiaparageusia, and general taste alterations. Moreover, we scored, according to Common Toxicity Criteria Adverse Events, nausea and other treatment-related toxicities. Since, ginger is traditionally used to prevent and/or treat nausea and vomiting, we prophylactically employed a ginger-based supplement named Naumix/Naugin (Gamfarma, Milan, Italy), to potentially mitigate both nausea and taste impairment. Using the CiTAS scale, we highlighted a progressive increase in all dysgeusia dimensions, peaking at the VII week of treatment and a subsequent partial late recovery. In particular, we observed a recovery for discomfort, phantogeusiaparageusia, and general taste alterations at 6 months. Grade 2 nausea, observed to be as low as 12.9% potentially due to the use of ginger, peaked at the III week of treatment. Finally, for patients experiencing nausea, the dysgeusia dimension of discomfort was also relevant.

Keywords

Nausea Dysgeusia Taste impairment Head and neck cancer Radiotherapy Chemotherapy Ginger 

Notes

Compliance with ethical standards

Conflict of interest

All the authors declare that they do not have any conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The present study has been reviewed and approved by the Internal Review Board of the Department of Oncology of the University of Turin at AOU Citta’ della Salute e della Scienza, Turin, Italy.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Franco P, Potenza I, Schena M, Riva G, Pecorari G, Demo PG, et al. Induction chemotherapy and sequential concomitant chemo-radiation in locally advanced head and neck cancers: how induction-phase intensity and treatment breaks may impact on clinical outcomes. Anticancer Res. 2015;35:6247–54.PubMedGoogle Scholar
  2. 2.
    Franco P, Fiorentino A, Dionisi F, et al. Combined modality therapy for thoracic and head and neck cancer: a review of updated literature based on a consensus meeting. Tumori. 2016;102:459–71.CrossRefGoogle Scholar
  3. 3.
    Franco P, Potenza I, Moretto F, Segantin M, Grosso M, Lombardo A, et al. Hypericum perforatum and neem oil for the management of acute skin toxicity in head and neck cancer patients undergoing radiation of chemo-radiation: a single-arm prospective observational study. Radiat Oncol. 2014;29:297.CrossRefGoogle Scholar
  4. 4.
    Franco P, Martini S, Di Muzio J, Cavallin C, Arcadipane F, Rampino M, et al. Prospective assessment of oral mucositis and its impact on quality of life and patient-reported outcomes during radiotherapy for head and neck. Med Oncol. 2017;34:81.CrossRefGoogle Scholar
  5. 5.
    Hovan AJ, Williams PM, Stevenson-Moore P, Wahlin YB, Ohrn KEO, Elting LS, et al. A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer. 2010;18:1081–7.CrossRefGoogle Scholar
  6. 6.
    Kano T, Kanda K. Development and validation of a chemotherapy-induced taste alteration scale. Oncol Nurs Forum. 2013;40:79–85.CrossRefGoogle Scholar
  7. 7.
    Campagna S, Gonnella S, Stuardi M, Sperlinga R, Cerponi M, Olivero M, et al. Italian validation of the chemotherapy induced taste alteration scale. Assist Inferm Ric. 2016;35:22–8.PubMedGoogle Scholar
  8. 8.
    Sozeri E, Kutluturkan S. The validity and reliability of turkish version of the chemotherapy-induced taste alteration scale (CiTAS). Clin Nurs Res. 2016;2:235–49.Google Scholar
  9. 9.
    McKenzie E, Zaki P, Raman S, Olson R, McFarlane T, DeAngelis C, et al. Radiation-induced nausea and vomiting: a comparison between MASCC/ESMO, ASCO, and NCCN antiemetic guidelines. Support Care Cancer. 2019;27:783–91.CrossRefGoogle Scholar
  10. 10.
    Dennis K, Zhang L, Lutz S, van Baardwijk A, van der Linden Y, Holt T, et al. International patterns of practice in the management of radiation therapy-induced nausea and vomiting. Int J Radiat Oncol Biol Phys. 2012;84:49–60.CrossRefGoogle Scholar
  11. 11.
    Maranzano E, De Angelis V, Pergolizzi S, Lupattelli M, Frata P, Spagnesi S, et al. A prospective observational trial on emesis in radiotherapy: analysis of 1020 patients recruited in 45 Italian radiation oncology centres. Radiother Oncol. 2010;94:36–41.CrossRefGoogle Scholar
  12. 12.
    Giacosa A, Morazzoni P, Bombardelli E, Riva A, Bianchi Porro G, Rondanelli M. Can nausea and vomiting be treated with ginger extract? Eur Rev Med Pharmacol Sci. 2015;19:1291–6.PubMedGoogle Scholar
  13. 13.
    Monroe AT, Reddy SC, Gibbs GL, White GA, Peddada AV. Factors associated with radiation-induced nausea and vomiting in head and neck cancer patients treated with intensity modulated radiation therapy. Radiother Oncol. 2008;87:188–94.CrossRefGoogle Scholar
  14. 14.
    Heckmann SM, Hujoel P, Habiger S, Friess W, Wichmann M, Heckmann JG, et al. Zinc gluconate in the treatment of dysgeusia—a randomized clinical trial. J Dent Res. 2005;84:35–8.CrossRefGoogle Scholar
  15. 15.
    Halyard MY. Taste and smell alterations in cancer patients—real problems with few solutions. J Support Oncol. 2009;7:68–9.PubMedGoogle Scholar
  16. 16.
    Steinback S, Hummel T, Böhner C, Berktold S, Hundt W, Kriner M, et al. Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies. J Clin Oncol. 2009;27:1899–905.CrossRefGoogle Scholar
  17. 17.
    Irune E, Dwivedi RC, Nutting CM, Harrington KJ. Treatment-related dysgeusia in head and neck cancer patients. Cancer Treat Rev. 2014;40:1106–17.CrossRefGoogle Scholar
  18. 18.
    Chencharick JD, Mossman KL. Nutritional consequences of the radiotherapy of head and neck cancer. Cancer. 1983;51:811–5.CrossRefGoogle Scholar
  19. 19.
    de Graeff A, de Leeuw JR, Ros WJ, Hordijk GJ, Blijham GH, Winnubst JA. Long-term quality of life of patients with head and neck cancer. Laryngoscope. 2000;110:98–106.CrossRefGoogle Scholar
  20. 20.
    Rampling T, King H, Mais KL, Humphris GM, Swindell R, Sykes A, et al. Quality of life measurement in the head and neck cancer radiotherapy clinic: is it feasible and worthwhile? Clin Oncol. 2003;15:205–10.CrossRefGoogle Scholar
  21. 21.
    Mowry SE, LoTempio MM, Sadeghi A, Wang KH, Wang MB. Quality of life outcomes in laryngeal and oropharyngeal cancer patients after chemoradiation. Otolaryngol Head Neck Surg. 2006;135:565–70.CrossRefGoogle Scholar
  22. 22.
    Fang FM, Chien CY, Tsai WL, Chen HC, Hsu HC, Lui CC, et al. Quality of life and survival outcome for patients with nasopharyngeal carcinoma receiving three-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy: a longitudinal study. Int J Radiat Oncol Biol Phys. 2008;72:356–64.CrossRefGoogle Scholar
  23. 23.
    Ryan JL, Heckler CE, Roscoe JA, Dakhil SR, Kirshner J, Flynn PJ, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer. 2012;20:1479–89.CrossRefGoogle Scholar
  24. 24.
    Marx W, McCarthy AL, Ried K, Vitetta L, McKavanagh D, Thomson D, et al. Can ginger ameliorate chemotherapy-induced nausea? Protocol of a randomized double blind, placebo-controlled trial. BMC Complement Altern Med. 2014;9:14–134.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Stefania Martini
    • 1
  • Giuseppe Carlo Iorio
    • 1
  • Francesca Arcadipane
    • 2
  • Francesco Olivero
    • 1
  • Patrick Silvetti
    • 1
  • Monica Rampino
    • 2
  • Paolo Garzino Demo
    • 3
  • Massimo Fasolis
    • 3
  • Giancarlo Pecorari
    • 4
  • Mario Airoldi
    • 5
  • Umberto Ricardi
    • 1
  • Pierfrancesco Franco
    • 1
    Email author
  1. 1.Department of Oncology, Radiation OncologyUniversity of Turin School of MedicineTurinItaly
  2. 2.Department of Oncology, Radiation OncologyAOU Citta’ Della Salute e Della ScienzaTurinItaly
  3. 3.Maxillofacial Surgery Division, Department of Surgical SciencesUniversity of TurinTurinItaly
  4. 4.1st ENT Division, Department of Surgical SciencesUniversity of TurinTurinItaly
  5. 5.2nd Medical Oncology Division, Department of OncologyAOU Città Della Salute e Della ScienzaTurinItaly

Personalised recommendations