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Medical Oncology

, 35:105 | Cite as

α-Viniferin activates autophagic apoptosis and cell death by reducing glucocorticoid receptor expression in castration-resistant prostate cancer cells

  • Kejun Cheng
  • Xi Liu
  • Lu Chen
  • Jian-Min Lv
  • Fa-Jun Qu
  • Xiu-Wu Pan
  • Lin Li
  • Xin-Gang Cui
  • Yi GaoEmail author
  • Dan-Feng Xu
Original Paper

Abstract

Prostate cancer (PCa) is one of the most commonly diagnosed urological malignancies. However, there are limited therapies for PCa patients who develop biochemical recurrence after androgen deprivation therapy (ADT). In the present study, we investigated the therapeutic efficacy and mechanism of α-Viniferin (KCV), an oligostilbene of trimeric resveratrol, against human PCa cells and found that it markedly inhibited the proliferation of LNCaP, DU145, and PC-3 cancer cells in a time- and dose-dependent manner, and had a strong cytotoxicity in non-androgen-dependent PCa cells. In addition, KCV inhibited AR downstream expression in LNCaP cells, and inhibited activation of GR signaling pathway in DU145 and PC-3. Further investigation indicated that KCV could induce cancer cell apoptosis through AMPK-mediated activation of autophagy, and inhibited GR expression in castration-resistant prostate cancer(CRPC). These findings suggest that KCV may prove to be a novel and effective therapeutic agent for the treatment of CRPC.

Keywords

α-Viniferin Autophagy Prostate cancer Glucocorticoid receptor AMPK 

Notes

Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (No. 81572525; No. 81170637).

Compliance with ethical standards

Conflict of interest

There is no conflict of interest in this manuscript.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Chemical Biology Center, Lishui Institute of Agricultural SciencesLishuiChina
  2. 2.Department of UrologyRuijin Hospital, Shanghai Jiaotong University School of MedicineShanghaiChina
  3. 3.Department of UrologyThird Affiliated Hospital, Second Military Medical UniversityShanghaiChina

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