Medical Oncology

, 35:87 | Cite as

Challenges and prospects of chimeric antigen receptor T cell therapy in solid tumors

  • Vishal JindalEmail author
  • Ena Arora
  • Sorab Gupta
Review Article


Chimeric antigen receptor (CAR) T cell therapy is a novel and innovative immunotherapy. CAR-T cells are genetically engineered T cells, carrying MHC independent specific antigen receptor and co-stimulatory molecule which can activate an immune response to a cancer specific antigen. This therapy showed great results in hematological malignancies but were unable to prove their worth in solid tumors. Likely reasons for their failure are lack of antigens, poor trafficking, and hostile tumor microenvironment. Excessive amount of research is going on to improve the efficacy of CAR T cell therapy in solid tumors. In this article, we will discuss the challenges faced in improving the outcome of CAR T cell therapy in solid tumors and various strategies adopted to curb them.


Chimeric antigen receptor T cell therapy Solid tumors Immunotherapy 



Special thanks to Dr. Manisha Dhananjaya.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.


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Authors and Affiliations

  1. 1.Department of Internal MedicineSaint Vincent HospitalWorcesterUSA
  2. 2.Department of Internal MedicineGovernment Medical CollegeChandigarhIndia
  3. 3.Department of Hematology and OncologyEinstein Healthcare NetworkPhiladelphiaUSA

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