Kefir: a powerful probiotics with anticancer properties
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Probiotics and fermented milk products have attracted the attention of scientists from various fields, such as health care, industry and pharmacy. In recent years, reports have shown that dietary probiotics such as kefir have a great potential for cancer prevention and treatment. Kefir is fermented milk with Caucasian and Tibet origin, made from the incubation of kefir grains with raw milk or water. Kefir grains are a mixture of yeast and bacteria, living in a symbiotic association. Antibacterial, antifungal, anti-allergic and anti-inflammatory effects are some of the health beneficial properties of kefir grains. Furthermore, it is suggested that some of the bioactive compounds of kefir such as polysaccharides and peptides have great potential for inhibition of proliferation and induction of apoptosis in tumor cells. Many studies revealed that kefir acts on different cancers such as colorectal cancer, malignant T lymphocytes, breast cancer and lung carcinoma. In this review, we have focused on anticancer properties of kefir.
KeywordsKefir Probiotics Cancer Anticancer
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Conflict of interest
All authors declare that they have no conflict of interest.
Human and animal rights
This article does not contain any studies with human participants or animals performed by any of the authors.
- 4.van’t Veer P, Dekker JM, Lamers JW, Kok FJ, Schouten EG, Brants HA, et al. Consumption of fermented milk products and breast cancer: a case-control study in The Netherlands. Can Res. 1989;49(14):4020–3.Google Scholar
- 7.Biffi A, Coradini D, Larsen R, Riva L, Di Fronzo G. Antiproliferative effect of fermented milk on the growth of a human breast cancer cell line. Nutr Cancer. 1997;28(1):93–9.Google Scholar
- 10.Garrote GL, Abraham AG, De Antoni GL. Microbial interactions in Kefir: a natural probiotic drink. In: Biotechnology of lactic acid bacteria: novel applications. Wiley-Blackwell; 2010. P. 327–36.Google Scholar
- 11.Farnworth ERT. Handbook of fermented functional foods. New York: CRC Press; 2008.Google Scholar
- 16.Hotel ACP, Cordoba A. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Prevention. 2001;5(1):1–10.Google Scholar
- 29.Sheikhi A, Jafarzadeh A. A new therapeutic potential for cancers: one CAR with 2 different engines! Hum Vaccin Immunother. 2017;13(8):1786–8.Google Scholar
- 30.Sheikhi A, Shakerian M, Giti H, Baghaeifar M, Jafarzadeh A, Ghaed V, et al. Probiotic yogurt culture bifidobacterium animalis subsp. lactis BB-12 and lactobacillus acidophilus LA-5 modulate the cytokine secretion by peripheral blood mononuclear cells from patients with ulcerative colitis. Drug Res. 2016;66(06):300–5.CrossRefGoogle Scholar
- 40.Pepe G, Tenore GC, Mastrocinque R, Stusio P, Campiglia P. Potential anticarcinogenic peptides from bovine milk. J Amino Acids. 2013;2013:1–7.Google Scholar
- 55.Rizk S, El Khoury N, El-Hayek S, Tarras O, El-sibai M, El-Sabban M. Kefir exhibits anti-proliferative and pro-apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion (647.24). FASEB J. 2014;28(1 Supplement):647–724.Google Scholar
- 56.Can G, Topuz E, Derin D, Durna Z, Aydiner A. Effect of kefir on the quality of life of patients being treated for colorectal cancer. Oncol Nurs Forum. 2009;36(6):335–42.Google Scholar
- 58.Alsha’ar IA, Aloklah B, Al-Deen RB, Aljamali M, Alkadry R, Albiski F. In vitro anticancer properties of kefir and kefir products produced by a novel method in Syria. IJPSI. 2017;6(5):1–6Google Scholar
- 60.Furukawa N, Matsuoka A, Takahashi T, Yamanaka Y. Anti-metastatic effect of kefir grain components on lewis lung carcinoma and highly metastatic B 16 melanoma in mice. J Agric Sci-Tokyo-Univ Agric. 2000;45(1):62–70.Google Scholar