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Prognostic value of ABO blood types in young patients with breast cancer; a nationwide study in Korean Breast Cancer Society

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Abstract

The purpose of this study was to investigate the relationship between ABO blood types and breast cancer survival in young Korean patients. This was a retrospective study of 115,474 patients who were surgically treated for primary breast cancer between 1987 and 2011 in Korea. All data were collected by the Korean Breast Cancer Society (KBCS) online breast cancer registry. Each hospital serologically examined the ABO blood types of patients before surgery. There was no significant difference in overall survival (OS) or breast cancer-specific survival (BCSS) among ABO blood types. Type of surgery; T stage; N stage; histologic grade; status of estrogen receptor, progesterone receptor, and HER2; and chemotherapy were significant prognostic factors of OS and BCSS in univariate analysis and multivariate analyses. Compared to women with blood type O, there was a difference in OS and BCSS for blood type A, blood type B, or blood type AB. Compared to blood group non-O, patients with blood group O were more likely to have favorable prognosis when younger than 40 years. Further follow-up studies are necessary to clarify the role of the impact of ABO blood types on prognosis of breast cancer.

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References

  1. Anders CK, Hsu DS, Broadwater G, Acharya CR, Foekens JA, Zhang Y, et al. Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol. 2008;26:3324–30.

    Article  PubMed  Google Scholar 

  2. Collins LC, Marotti JD, Gelber S, Cole K, Ruddy K, Kereakoglow S, et al. Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer. Breast Cancer Res Treat. 2012;131:1061–6.

    Article  CAS  PubMed  Google Scholar 

  3. Carey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA. 2006;295:2492–502.

    Article  CAS  PubMed  Google Scholar 

  4. O’Brien KM, Cole SR, Tse CK, Perou CM, Carey LA, Foulkes WD, et al. Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study. Clin Cancer Res. 2010;16:6100–10.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Bauer KR, Brown M, Cress RD, Parise CA, Caggiano V. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry. Cancer. 2007;109:1721–8.

    Article  PubMed  Google Scholar 

  6. Hakomori S. Tumor-associated carbohydrate antigens. Annu Rev Immunol. 1984;2:103–26.

    Article  CAS  PubMed  Google Scholar 

  7. Yazer MH. What a difference 2 nucleotides make: a short review of ABO genetics. Transfus Med Rev. 2005;19:200–9.

    Article  PubMed  Google Scholar 

  8. Wolpin BM, Chan AT, Hartge P, Chanock SJ, Kraft P, Hunter DJ, et al. ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst. 2009;101:424–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Xie J, Qureshi AA, Li Y, Han J. ABO blood group and incidence of skin cancer. PLoS ONE. 2010;5:e11972.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Stamatakos M, Kontzoglou K, Safioleas P, Safioleas C, Manti C, Safioleas M. Breast cancer incidence in Greek women in relation to ABO blood groups and Rh factor. Int Semin Surg Oncol. 2009;6:14.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Tryggvadottir L, Tulinius H, Robertson JM. Familial and sporadic breast cancer cases in Iceland: a comparison related to ABO blood groups and risk of bilateral breast cancer. Int J Cancer. 1988;42:499–501.

    Article  CAS  PubMed  Google Scholar 

  12. Holdsworth PJ, Thorogood J, Benson EA, Clayden AD. Blood group as a prognostic indicator in breast cancer. Br Med J (Clin Res Ed). 1985;290:671–3.

    Article  CAS  Google Scholar 

  13. Han W, Kim SW, Park IA, Kang D, Kim SW, Youn YK, et al. Young age: an independent risk factor for disease-free survival in women with operable breast cancer. BMC Cancer. 2004;4:82.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Azim HA Jr, Partridge AH. Biology of breast cancer in young women. Breast Cancer Res. 2014;16:427.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Fisher ER, Anderson S, Tan-Chiu E, Fisher B, Eaton L, Wolmark N. Fifteen-year prognostic discriminants for invasive breast carcinoma: National Surgical Adjuvant Breast and Bowel Project Protocol-06. Cancer. 2001;91:1679–87.

    Article  CAS  PubMed  Google Scholar 

  16. Kroman N, Jensen MB, Wohlfahrt J, Mouridsen HT, Andersen PK, Melbye M. Factors influencing the effect of age on prognosis in breast cancer: population based study. BMJ. 2000;320:474–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Colleoni M, Rotmensz N, Robertson C, Orlando L, Viale G, Renne G, et al. Very young women (<35 years) with operable breast cancer: features of disease at presentation. Ann Oncol. 2002;13:273–9.

    Article  CAS  PubMed  Google Scholar 

  18. Carvalho FM, Bacchi LM, Santos PP, Bacchi CE. Triple-negative breast carcinomas are a heterogeneous entity that differs between young and old patients. Clinics (Sao Paulo). 2010;65:1033–6.

    Article  Google Scholar 

  19. Coussens L, Yang-Feng TL, Liao YC, Chen E, Gray A, McGrath J, et al. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science. 1985;230:1132–9.

    Article  CAS  PubMed  Google Scholar 

  20. Anstee DJ. The relationship between blood groups and disease. Blood. 2010;115:4635–43.

    Article  CAS  PubMed  Google Scholar 

  21. Liumbruno GM, Franchini M. Beyond immunohaematology: the role of the ABO blood group in human diseases. Blood Transfus. 2013;11:491–9.

    PubMed  PubMed Central  Google Scholar 

  22. Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci. 2012;49:137–49.

    Article  CAS  PubMed  Google Scholar 

  23. Lee AK, DeLellis RA, Rosen PP, Saigo PE, Gangi MD, Bagin R, et al. ABH blood group isoantigen expression in breast carcinomas–an immunohistochemical evaluation using monoclonal antibodies. Am J Clin Pathol. 1985;83:308–19.

    Article  CAS  PubMed  Google Scholar 

  24. Le Pendu J, Marionneau S, Cailleau-Thomas A, Rocher J, Le Moullac-Vaidye B, Clement M. ABH and Lewis histo-blood group antigens in cancer. Apmis. 2001;109:9–31.

    Article  PubMed  Google Scholar 

  25. Engelmann B, Schumacher U, Haen E. Epidermal growth factor binding sites on human erythrocytes in donors with different ABO blood groups. Am J Hematol. 1992;39:239–41.

    Article  CAS  PubMed  Google Scholar 

  26. Barbalic M, Dupuis J, Dehghan A, Bis JC, Hoogeveen RC, Schnabel RB, et al. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet. 2010;19:1863–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet. 2008;4:e1000072.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Qi L, Cornelis MC, Kraft P, Jensen M, van Dam RM, Sun Q, et al. Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes. Hum Mol Genet. 2010;19:1856–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Witkowska AM, Borawska MH. Soluble intercellular adhesion molecule-1 (sICAM-1): an overview. Eur Cytokine Netw. 2004;15:91–8.

    CAS  PubMed  Google Scholar 

  30. Rahbari NN, Bork U, Hinz U, Leo A, Kirchberg J, Koch M, et al. AB0 blood group and prognosis in patients with pancreatic cancer. BMC Cancer. 2012;12:319.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Gates MA, Xu M, Chen WY, Kraft P, Hankinson SE, Wolpin BM. ABO blood group and breast cancer incidence and survival. Int J Cancer. 2012;130:2129–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Klimant E, Glurich I, Mukesh B, Onitilo AA. Blood type, hormone receptor status, HER2/neu status, and survival in breast cancer: a retrospective study exploring relationships in a phenotypically well-defined cohort. Clin Med Res. 2011;9:111–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Zouine S, Marnissi F, Otmani N, Bennani Othmani M, El Wafi M, Kojok K, et al. ABO blood groups in relation to breast carcinoma incidence and associated prognostic factors in Moroccan women. Med Oncol. 2016;33:67.

    Article  CAS  PubMed  Google Scholar 

  34. Park B, Choi KS, Lee YY, Jun JK, Seo HG. Trends in cancer screening rates among Korean men and women: results from the Korean National Cancer Screening Survey (KNCSS), 2004–2011. Cancer Res Treat. 2012;44:113–20.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgement

This article was supported by the Korean Breast Cancer Society.

Author information

Authors and Affiliations

  1. Department of Surgery, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, South Korea

    Sungmin Park

  2. Breast-Thyroid Center, Ulsan City Hospital, Ulsan City Hospital Group, Ulsan, South Korea

    Ku Sang Kim

  3. Department of Surgery, Uijeongbu St. Mary’s Hospital, Catholic University, Uijeongbu, South Korea

    Jeong-Soo Kim

  4. Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea

    Wonshik Han

  5. Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea

    Byeong-Woo Park

  6. Department of Surgery, Pusan National University Hospital, Pusan National University College of Medicine, Busan, South Korea

    Seokwon Lee

  7. Department of Surgery, St. Vincent’s Hospital, College of Medicine, Catholic University, Suwon, South Korea

    Ye Won Jeon

  8. Division of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Se Kyung Lee, Jonghan Yu, Jeong Eon Lee, Seok Won Kim & Seok Jin Nam

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  1. Sungmin Park
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Consortia

Korean Breast Cancer Society

Contributions

Sungmin Park, Se Kyung Lee, and Seok Jin Nam designed the research. Sungmin Park, Se Kyung Lee, Seok Jin Nam, Ku Sang Kim, Jeong-Soo Kim, Wonshik Han, Byeong-Woo Park, Seokwon Lee, Ye Won Jeon, Jonghan Yu, Jeong Eon Lee, Seok Won Kim, and Korean Breast Cancer Society Consortium carried out the data collection, analysis and interpretation of data, and drafted the article. Sungmin Park, Se Kyung Lee, and Seok Jin Nam analyzed the data and wrote the article. All authors participated in revising the article and reached final approval of the version to be published.

Corresponding author

Correspondence to Seok Jin Nam.

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Conflict of interest

The authors declare that they have no conflict of interest in this manuscript, including financial, consultant, institutional, or other relationships that might lead to bias.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The requirement to obtain informed consent was waived by the institutional review board.

Additional information

Sungmin Park and Se Kyung Lee shared co-first authorship.

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Park, S., Kim, K.S., Kim, JS. et al. Prognostic value of ABO blood types in young patients with breast cancer; a nationwide study in Korean Breast Cancer Society. Med Oncol 34, 118 (2017). https://doi.org/10.1007/s12032-017-0974-6

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  • DOI: https://doi.org/10.1007/s12032-017-0974-6

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