Systematic review: isocaloric ketogenic dietary regimes for cancer patients
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The efficacy and benefits of ketogenic diets (KD) have recently been gaining worldwide and remain a controversial topic in oncology. This systematic review therefore presents and evaluates the clinical evidence on isocaloric KD dietary regimes and reveals that evidence supporting the effects of isocaloric ketogenic dietary regimes on tumor development and progression as well as reduction in side effects of cancer therapy is missing. Furthermore, an array of potential side effects should be carefully considered before applying KD to cancer patients. In regard to counseling cancer patients considering a KD, more robust and consistent clinical evidence is necessary before the KD can be recommended for any single cancer diagnosis or as an adjunct therapy.
KeywordsCancer Ketogenic diet Nutrition Cancer diet Low carbohydrate Oncology
Compliance with ethical standards
Conflict of interest
Nicole Erickson has received a speaker honorarium from B. Braun, CSL-Behring and Fresenius Kabi. The content of these talks was not related to the content of this article. A. Boscheri, B. Linke and J. Huebner declare no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors and therefore did not require ethical approval.
- 5.Neuropädiatrie GF. S1-Leitline 022/21: Ketogene Diäten. AWMF Online Register; 2014.Google Scholar
- 18.EPaOoC (EPOC). EPOC resources for review authors. Norwegian Knowledge Centre for the Health Services. http://epoc.cochrane.org/epoc-specific-resources-review-authors.
- 28.Fine EJ, Segal-Isaacson CJ, Feinman RD, Herszkopf S, Romano MC, Tomuta N, et al. Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. Nutrition. 2012;28(10):1028–35. doi: 10.1016/j.nut.2012.05.001.CrossRefPubMedGoogle Scholar
- 33.Tan-Shalaby JL, Carrick J, Edinger K, Genovese D, Liman AD, Passero VA, et al. Modified Atkins diet in advanced malignancies—final results of a safety and feasibility trial within the Veterans Affairs Pittsburgh Healthcare System. Nutr Metab (Lond). 2016;13:52. doi: 10.1186/s12986-016-0113-y.CrossRefGoogle Scholar