Medical Oncology

, 34:67 | Cite as

Percutaneous needle biopsy of mediastinal masses under C-arm conebeam CT guidance: diagnostic performance and safety

  • Chiara Floridi
  • Alfonso Reginelli
  • Raffaella Capasso
  • Enrico Fumarola
  • Filippo Pesapane
  • Antonio Barile
  • Marcello Zappia
  • Ferdinando Caranci
  • Luca BruneseEmail author
Original Paper
Part of the following topical collections:
  1. New Advances in Interventional Oncology: State of the Art


The aim of this study is to evaluate the feasibility of percutaneous needle biopsy of mediastinal masses under conebeam computed tomography (CBCT) and “XperGuide” navigation guidance. From September 2013 to April 2016, 40 patients (25 men and 15 women; mean age 52.5 years; range 18.7–86.4 years) with 40 mediastinal masses underwent CBCT-/”XperGuide”-guided percutaneous needle biopsies. Technical success, sensibility, specificity, positive predictive value (ppv), negative predictive value (npv) and complications rate were evaluated. Technical success evaluated as the correct positioning of the needle inside the lesion was 100%. Based on histopathological diagnosis, 2 of 40 biopsies (5%) resulted a false negative. Diagnostic accuracy was 95%, sensitivity was 95%, specificity was 100%, ppv was 100%, and npv was 33%. The mean total procedure time was 32 min (range 15–60 min) revealing a reduction in time comparing the first group of 20 patients (mean time 45 min) with the last group of 20 patients (mean time 17 min). No major complications were recorded. Only three patients (7.5%) had mild pneumothorax as demonstrated by post-procedural CBCT, resolved spontaneously. CBCT/“XperGuide” navigation system is a new, safe and accurate technique that can be used as guidance for mediastinal mass biopsies. It also permits the use of CT machines for diagnostic examinations relieving them from interventional procedures burden.


C-arm conebeam CT Percutaneous biopsy Imaging guidance Mediastinal masses 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Chiara Floridi
    • 1
  • Alfonso Reginelli
    • 2
  • Raffaella Capasso
    • 3
  • Enrico Fumarola
    • 4
  • Filippo Pesapane
    • 4
  • Antonio Barile
    • 5
  • Marcello Zappia
    • 3
  • Ferdinando Caranci
    • 3
  • Luca Brunese
    • 3
    Email author
  1. 1.Radiology DepartmentInsubria UniversityVareseItaly
  2. 2.Department of Internal and Experimental MedicineSecond University of NaplesNaplesItaly
  3. 3.Department of RadiologyUniversity of MoliseCampobassoItaly
  4. 4.Department of Health Sciences, Diagnostic and Interventional Radiology, San Paolo HospitalUniversity of MilanMilanItaly
  5. 5.Department of Biotechnological and Applied Clinical SciencesUniversity of l’AquilaL’AquilaItaly

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