Medical Oncology

, 34:55 | Cite as

Intra-articular benign bone lesions treated with Magnetic Resonance-guided Focused Ultrasound (MRgFUS): imaging follow-up and clinical results

  • Francesco ArrigoniEmail author
  • Antonio Barile
  • Luigi Zugaro
  • Alessandra Splendiani
  • Ernesto Di Cesare
  • Ferdinando Caranci
  • Anna Maria Ierardi
  • Chiara Floridi
  • Alessio Salvatore Angileri
  • Alfonso Reginelli
  • Luca Brunese
  • Carlo Masciocchi
Original Paper
Part of the following topical collections:
  1. New Advances in Interventional Oncology: State of the Art


Purpose of this study was to evaluate the employment of MRI-guided Focused Ultrasound (MRgFUS) for treatment of intra-articular benign bone lesions as alternative to surgery, and to monitor the success of the treatment on CT and MRI images. From March 2011 to August 2013, 14 intra-articular benign bone lesions were treated with MRgFUS. All patients were studied by CT and MR imaging. Pain was measured using the visual analogue scale (VAS) before and after treatment (6 and 12 months). All patients in our series demonstrated regression in painful symptomatology during screening. A significant drop in the mean VAS pain score (from 7.8 to 0.6) was observed at 12-month follow-up, and pain medication was no longer needed after treatment. No complications were observed. Three diagnostic imaging signs were found suggesting absence of biological activity and confirming the clinical findings: calcification of the treated lesion, lack of contrast enhancement and disappearance of bone oedema around the lesions. Conclusion: the employment of MRgFUS is safe and effective in the treatment of intra-articular benign bone lesions. The clinical outcome is satisfactory, and the success of the treatment is confirmed by diagnostic imaging.


MRgFUS Benign bone lesions Thermoablation Intrarticular bone lesions Interventional radiology Osteoid Osteoma 



We are grateful to Angela Martella for translation of the manuscript.

Compliance with ethical standards

Conflict of interest


Informed consent

All procedures performed in these studies were in accordance with the Helsinki Declaration and its later amendments; an informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Francesco Arrigoni
    • 1
    Email author
  • Antonio Barile
    • 1
  • Luigi Zugaro
    • 1
  • Alessandra Splendiani
    • 1
  • Ernesto Di Cesare
    • 1
  • Ferdinando Caranci
    • 2
  • Anna Maria Ierardi
    • 3
  • Chiara Floridi
    • 3
  • Alessio Salvatore Angileri
    • 4
  • Alfonso Reginelli
    • 5
  • Luca Brunese
    • 2
  • Carlo Masciocchi
    • 1
  1. 1.Diagnostic and Interventional Radiology, Department of Applied Clinical Science and BiotechnologyUniversity of L’AquilaL’AquilaItaly
  2. 2.Department of Medicine and Health Science “V. Tiberio”University of MoliseCampobassoItaly
  3. 3.Department of RadiologyInsubria UniversityVareseItaly
  4. 4.Diagnostic and Interventional Radiology UnitUniversity of MilanMilanItaly
  5. 5.Department of Internal and Experimental Medicine, Magrassi-Lanzara, Institute of RadiologySecond University of NaplesNaplesItaly

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