Medical Oncology

, 34:26

KRAS, NRAS and BRAF mutations in colorectal cancer and melanoma

  • Jonas Cicenas
  • Linas Tamosaitis
  • Kotryna Kvederaviciute
  • Ricardas Tarvydas
  • Gintare Staniute
  • Karthik Kalyan
  • Edita Meskinyte-Kausiliene
  • Vaidotas Stankevicius
  • Mindaugas Valius
Review Article

DOI: 10.1007/s12032-016-0879-9

Cite this article as:
Cicenas, J., Tamosaitis, L., Kvederaviciute, K. et al. Med Oncol (2017) 34: 26. doi:10.1007/s12032-016-0879-9

Abstract

Cancers are the group of diseases, which arise because of the uncontrolled behavior of some of the genes in our cells. There are possibilities of gene amplifications, overexpressions, deletions and other anomalies which might lead to the development and spread of cancer. One of the most dangerous ways to the cancers is the mutations of the genes. The mutated genes can start unstoppable proliferation of cells, their uncontrolled motility, protection from apoptosis, the DNA mutation enhancement as well as other anomalies, leading to the cancer. This review focuses on the genes, which are frequently mutated in various cancers and are known to be important in the advance and progression of colorectal cancer and melanoma, namely KRAS, NRAS and BRAF.

Keywords

KRAS NRAS BRAF GTPase Kinase Melanoma Colorectal cancer Squamous cell anal cancer Mutation 

Funding information

Funder NameGrant NumberFunding Note
Scientific Council of Lithuania
  • MIP-033/2014

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Jonas Cicenas
    • 1
    • 2
    • 3
  • Linas Tamosaitis
    • 4
  • Kotryna Kvederaviciute
    • 5
  • Ricardas Tarvydas
    • 2
  • Gintare Staniute
    • 2
  • Karthik Kalyan
    • 2
    • 6
  • Edita Meskinyte-Kausiliene
    • 7
  • Vaidotas Stankevicius
    • 8
  • Mindaugas Valius
    • 3
  1. 1.Vetsuisse Faculty, Institute of Animal PathologyUniversity of BernBernSwitzerland
  2. 2.MAP Kinase ResourceBernSwitzerland
  3. 3.Proteomics CentreVilnius University Institute of BiochemistryVilniusLithuania
  4. 4.School of BiosciencesUniversity of KentCanterburyUK
  5. 5.Institute of BiotechnologyVilnius UniversityVilniusLithuania
  6. 6.The International Immunogenetics Information System (IMGT); Institut de Genitique Humaine (IGH), CNRSMontpellier Cedex 5France
  7. 7.Aleksandro Stulginskio UniversityAkademijaLithuania
  8. 8.Lithuania National Cancer InstituteVilniusLithuania

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