Medical Oncology

, 32:156 | Cite as

The impact of hypoxemia on serum total and free prostate-specific antigen levels in patients with chronic obstructive pulmonary disease

  • Cengiz Ozge
  • Murat BozluEmail author
  • Eylem Sercan Ozgur
  • Mesut Tek
  • Ahmet Tunckiran
  • Necati Muslu
  • Ahmet Ilvan
Original Paper


Prostate-specific antigen (PSA) is the most important biochemical marker in the diagnosis and follow-up of patients with prostate cancer. In recent years, a relationship between PSA levels and hypoxic conditions has been described. However, no study has investigated the PSA levels in patients with chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate the impact of hypoxemia on serum total (tPSA) and free PSA (fPSA) levels in patients with COPD. Between January 2010 and January 2014, 95 male patients who hospitalized for acute exacerbations of COPD and 80 control subjects were enrolled in the study. Serum tPSA and fPSA levels and f/tPSA ratios were determined in all patients on the first day of hospitalization (exacerbation) and 7 days after the treatment (stable state). Statistical analysis included paired t test and Mann–Whitney U test. No statistically significant differences were found between COPD and control groups with regard to the baseline characteristics, except for smoking status. The levels of serum tPSA and fPSA during exacerbation of COPD were significantly higher than the levels of the stable period (p < 0.01), whereas f/tPSA ratio did not change (p > 0.05). Hypoxemia during acute exacerbation of COPD can cause a rise in serum tPSA and fPSA levels, but f/tPSA ratio is not affected. Acute exacerbation of COPD may be added to list of the events in which PSA measurements must be interpreted with caution.


Chronic obstructive pulmonary disease Hypoxia Prostate Prostate-specific antigen 


Conflict of interest



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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Cengiz Ozge
    • 1
  • Murat Bozlu
    • 2
    Email author
  • Eylem Sercan Ozgur
    • 1
  • Mesut Tek
    • 2
  • Ahmet Tunckiran
    • 4
  • Necati Muslu
    • 3
  • Ahmet Ilvan
    • 1
  1. 1.Department of Chest DiseasesUniversity of Mersin School of MedicineMersinTurkey
  2. 2.Department of UrologyUniversity of Mersin School of MedicineMersinTurkey
  3. 3.Department of BiochemistryUniversity of Mersin School of MedicineMersinTurkey
  4. 4.Department of Urology, Faculty of Medicine, Alanya Practice and Research CenterBaskent UniversityAlanyaTurkey

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