Suppressed expression of LDHB promotes pancreatic cancer progression via inducing glycolytic phenotype
- 1.1k Downloads
Lactate dehydrogenase B (LDHB) is widely expressed in adult somatic tissue and is one of the two subunits of lactate dehydrogenase, which is the key glycolytic enzyme and catalyzes the interconversion of pyruvate and lactate. However, the roles of LDHB in glycolysis and tumor progression were obscure in different types of cancer. Here, we determined the roles of LDHB in pancreatic cancer development and progression. We found suppressed expression of LDHB in pancreatic cancer which was due to promoter hypermethylation and deceased expression of LDHB led to glycolytic transition. Functional analysis revealed that suppressed expression of LDHB promoted pancreatic cancer cells proliferation, invasion, and migration in hypoxia. Thus, LDHB might function as a suppressor of glycolysis and suppressed pancreatic cancer progression.
KeywordsLDHB Metastasis Growth Pancreatic cancer
Supported by Shanghai Jiao Tong University Oversea Training Scholarship (to J. Cui and M. Quan); Grants 81171887 and 91229117 from the National Natural Science Foundation of China (to L. Wang).
Conflict of interest
No potential conflicts of interest were disclosed.
The use of the tissue microarray was approved by the medical ethics committee.
- 7.Koukourakis MI, Giatromanolaki A, Sivridis E, Bougioukas G, Didilis V, Gatter KC, Harris AL. Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. Br J Cancer. 2003;89:877–85.CrossRefPubMedCentralPubMedGoogle Scholar