Medical Oncology

, 32:79 | Cite as

A phase II study of arsenic trioxide in patients with relapsed or refractory malignant lymphoma

  • Hongli Zhao
  • Guoxun Sun
  • Desheng Kong
  • Yujing Zhang
  • Wudan Shi
  • Mingming Zhao
  • Luojia Hong
  • Zhenkui QiaoEmail author
Original Paper


Limited data have been reported regarding the use of arsenic trioxide (ATO) in the treatment of patients with relapsed or refractory malignant lymphoma; therefore, the present phase II study evaluated the efficacy and toxicity of ATO in such patients. A total of 35 patients were treated with ATO (0.25 mg/kg) infused for 1 h daily, 5 days a week, for a 6-week cycle. Patients were evaluated for the efficacy and toxicity of this regimen. The primary outcome evaluated was the overall response rate (ORR), including the complete and partial response rates. The secondary outcomes evaluated were the overall survival (OS), progression-free survival (PFS), and toxicity. Tumor response data were obtained from all 35 enrolled patients. The ORR was 43 %, including complete responses in four patients (11 %) and partial responses in 11 patients (31 %). The median duration of response was 16 weeks (range 11–23 weeks). The median OS was 79 weeks (range 14–171 weeks), and the median PFS was 55 weeks (range 14–135 weeks). Grade I or II hematological toxicities were the most commonly reported adverse events. The results of this study appear promising for the treatment of relapsed or refractory malignant lymphoma, with well-tolerated ATO toxicity.


Arsenic trioxide Lymphoma Non-Hodgkin lymphoma Hodgkin lymphoma 



This study was funded by Heilongjiang Province Science Foundation for Youths (Grant No.QC2012C106).

Conflict of interest

The authors declare that they have no competing interests.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Hongli Zhao
    • 1
  • Guoxun Sun
    • 1
  • Desheng Kong
    • 1
  • Yujing Zhang
    • 1
  • Wudan Shi
    • 1
  • Mingming Zhao
    • 1
  • Luojia Hong
    • 1
  • Zhenkui Qiao
    • 1
    Email author
  1. 1.Department of HematologyFourth Affiliated Hospital of Harbin Medical UniversityHarbinChina

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