MicroRNA-130a is down-regulated in hepatocellular carcinoma and associates with poor prognosis
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MicroRNA-130a (miR-130a) has recently been found to be implicated in many critical processes in various types of human cancer. However, the prognostic value of miR-130a in hepatocellular carcinoma (HCC) remains unclear. In the present study, we investigated the expression of miR-130a in HCC and analyzed its association with clinical features and prognosis of HCC patients. We determined the expression level of miR-130a in 102 cases of paired HCC and adjacent non-tumor tissues by quantitative real-time PCR (qRT-PCR). The qRT-PCR results showed that the miR-130a expression was significantly down-regulated in tumor tissues compared with the adjacent non-tumor tissues (P < 0.001). Correlation analysis showed that miR-130a expression was significantly correlated with gender (P = 0.008), HBsAg status (P = 0.038), tumor size (P = 0.003), and tumor-node-metastasis stage (P = 0.029). Kaplan–Meier analysis showed that patients with low miR-130a expression had a poorer overall survival than patients with high miR-130a expression (log-rank P = 0.007). The multivariate Cox regression analysis indicated that miR-130a expression was an independent prognostic factor for overall survival (hazard ratio 2.217; 95 % CI 1.103–4.458; P = 0.025). The present study showed for the first time that miR-130a expression was significantly down-regulated in HCC and associated with overall survival of patients with HCC. The present study also provided evidence that miR-130a was an independent prognostic factor and could serve as a potential prognostic biomarker for patients with HCC.
KeywordsmiR-130a Hepatocellular carcinoma Real-time PCR Prognosis
This work was supported in part by grants from the National Natural Science Foundation of China (81101863 and 81172344), Guangdong Natural Science Foundation (S2011040004570), and the Fundamental Research Funds for the Central Universities (11ykpy60).
Conflict of interest
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