Prognostic significance of serum beta-2 microglobulin level in Hodgkin lymphoma treated with ABVD-based therapy
- 203 Downloads
- 2 Citations
Abstract
The levels of serum beta-2 microglobulin (β2MG) are determined mainly from lymphoid tissue. To examine its prognostic value in Hodgkin lymphoma (HL), we conducted a retrospective analysis. We analyzed 67 patients with HL diagnosed and treated at seven institutes of the Yokohama City University Hematology Group between 1998 and 2011. The patients included 40 males and 27 females with a median age of 41 years (range 16–81 years). The HL subtypes were nodular sclerosis classical HL in 37 patients, mixed cellular classical HL in 23, lymphocyte-rich classical HL in 6, and nodular lymphocyte-predominant HL in 1. The 4-year overall survival (OS) rate of all 67 patients was 89 %. Patients with β2MG levels ≥2.5 mg/L (n = 18) showed inferior progression-free survival (PFS; 4-year PFS rate, 42 %) and inferior OS (4-year OS rate, 60 %) compared to patients who had β2MG levels <2.5 mg/L (n = 49; 4-year PFS rate, 87 %; 4-year OS rate, 98 %; P < 0.001). In multivariate analysis, only a serum β2MG level ≥2.5 mg/L was a significant adverse prognostic factor in regard to PFS (P = 0.04; relative risk 3.57). However, it was not significant prognostic factor for OS (P = 0.16) in the multivariate analysis. The serum β2MG level at diagnosis is a useful prognostic marker in patients with HL.
Keywords
Serum beta-2 microglobulin Hodgkin lymphoma Prognostic markerNotes
Conflict of interest
The authors declare that they have no conflict of interest.
References
- 1.Hasenclever D, Diehl V. A prognostic score for advanced Hodgkin’s disease. International prognostic factors project on advanced Hodgkin’s disease. N Engl J Med. 1998;339:1506–14.PubMedCrossRefGoogle Scholar
- 2.Axdorph U, Sjöberg J, Grimfors G, Landgren O, Porwit-MacDonald A, Björkholm M. Biological markers may add to prediction of outcome achieved by the international prognostic score in Hodgkin’s disease. Ann Oncol. 2000;11:1405–11.PubMedCrossRefGoogle Scholar
- 3.Thompson CA, Maurer MJ, Cerhan JR, et al. Elevated serum free light chains are associated with inferior event free and overall survival in Hodgkin lymphoma. Am J Hematol. 2011;86:998–1000.PubMedCrossRefPubMedCentralGoogle Scholar
- 4.Child JA, Spati B, Illingworth S, et al. Serum beta 2 microglobulin and C-reactive protein in the monitoring of lymphomas. Cancer. 1980;45:318–26.PubMedCrossRefGoogle Scholar
- 5.Greipp PR, Miguel JS, Durie BGM, et al. International staging system for multiple myeloma. J Clin Oncol. 2005;23:3412–20.PubMedCrossRefGoogle Scholar
- 6.Decaux O, Renault A, Sébille V, et al. On behalf of the Intergroupe Francophone du Myéloma (IFM). Predictive factors of survival after thalidomide therapy in advanced multiple myeloma: long-term follow-up of a prospective multicenter nonrandomized phase II study in 120 patients. Clin Lymphoma Myeloma Leuk. 2012;12:418–422.Google Scholar
- 7.Constantinides IP, Pathouli C, Karvountzis G, et al. Serum beta 2 microglobulin in malignant lymphoproliferative disorders. Cancer. 1985;55:2384–9.PubMedCrossRefGoogle Scholar
- 8.Johnson PW, Whelan J, Longhurst S, et al. Beta-2 microglobulin: a prognostic factor in diffuse aggressive non-Hodgkin’s lymphomas. Br J Cancer. 1993;67:792–7.PubMedCrossRefPubMedCentralGoogle Scholar
- 9.Federico M, Guglielmi C, Luminari S, et al. Prognostic relevance of serum β2 microglobulin in patients with follicular lymphoma treated with anthracycline-containing regimens. A GISL study. Haematologica. 2007;92:1482–1488.Google Scholar
- 10.Bairey O, Bar-Natan M, Shpilberg O. Early death in patients diagnosed with non-Hodgkin’s lymphoma. Ann Hematol. 2013;92:345–50.PubMedCrossRefGoogle Scholar
- 11.Li ZM, Zhu YJ, Sun J, et al. Serum beta2-microglobulin is a predictor of prognosis in patients with upper aerodigestive tract NK/T-cell lymphoma. Ann Hematol. 2012;91:1265–70.PubMedCrossRefGoogle Scholar
- 12.Chronowski GM, Wilder RB, Tucker SL, et al. An elevated serum beta-2-microglobulin level is an adverse prognostic factor for overall survival in patients with early-stage Hodgkin disease. Cancer. 2002;95:2534–8.PubMedCrossRefGoogle Scholar
- 13.Dimopoulos MA, Cabanillas F, Lee JJ, et al. Prognostic role of serum β2-microglobulin in Hodgkin`s disease. J Clin Oncol. 1993;11:1108–11.PubMedGoogle Scholar
- 14.Albitar M, Vose JM, Johnson MM, et al. Clinical relevance of soluble HLA-I and β2-microglobulin levels in non-Hodgkin’s lymphoma and Hodgkin’s disease. Leuk Res. 2007;31:139–45.PubMedCrossRefGoogle Scholar
- 15.Itoh K, Kinoshita T, Watanabe T, et al. Prognostic analysis and a new risk model for Hodgkin lymphoma in Japan. Int J Hematol. 2010;91:446–55.PubMedCrossRefGoogle Scholar
- 16.Vassilakopoulos TP, Nadali G, Angelopoulou MK, et al. The prognostic significance of beta-2 microglobulin in patients with Hodgkin’s lymphoma. Haematologica. 2002;87:701–8.PubMedGoogle Scholar
- 17.Cheson BD, Pfistner B, Juweid ME, et al. Revised response criteria for malignant lymphoma. J Clin Oncol. 2007;25:579–86.PubMedCrossRefGoogle Scholar
- 18.Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48:452–8.PubMedCrossRefPubMedCentralGoogle Scholar