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Medical Oncology

, 30:726 | Cite as

CRM1 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas

  • Fang Zhou
  • Wensheng Qiu
  • Ruyong Yao
  • Jinyu Xiang
  • Xiaoxiao Sun
  • Shihai Liu
  • Jing Lv
  • Lu Yue
Original Paper

Abstract

Gastric cancer (GC) is a highly aggressive malignant tumor. Its high mortality rate prompts the urgent need for novel therapeutic agents. The aim of this study is to detect the expression of CRM1 in GC, which has not been reported to date. The expression of CRM1 in GC and adjacent noncancerous tissues (ANCT) of gastrectomy specimens from 120 GC patients was measured by immunohistochemistry. In addition, correlations between the CRM1 staining and the clinicopathologic features as well as survival were analyzed. Positive expression rates of CRM1 in GC and ANCT were 57.8 and 6.7 %, respectively. High expression of CRM1 was significantly associated with increased serum level of carcinoma embryonic antigen (CEA, P = 0.02) but not associated with that of carbohydrate antigen 19–9 (P = 0.38). CRM1 levels were correlated with more advanced tumor stages (P = 0.01), positive Her2 status (P = 0.01), and distant metastasis (P = 0.02). Univariate analysis showed that CEA (P = 0.0076), TNM stage (P = 0.0001), metastasis (P = 0.027), and CRM1 expression (P = 0.0019) were significant risk factors affecting overall survival of GC patients. The multivariate analysis indicated that the CRM1 was an independent indicator for GC survival (P = 0.0048). The current results indicated that CRM1 expressed in a subpopulation of GC with aggressive behavior and could serve as a prognosis marker for poor outcome.

Keywords

Gastric cancer CRM1 Biomarker Prognosis 

Notes

Acknowledgments

This study is supported by Shandong Natural Science Foundation (2009HW024), Shandong Excellent Young Scientist Research Award Fund Project (2006BSB14114), and Shandong Tackle Key Problems in Science and Technology (2010GSF10245).

Conflict of interest

We have no conflicts of interest to report.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Fang Zhou
    • 1
    • 2
  • Wensheng Qiu
    • 1
  • Ruyong Yao
    • 3
  • Jinyu Xiang
    • 1
    • 4
  • Xiaoxiao Sun
    • 1
  • Shihai Liu
    • 3
  • Jing Lv
    • 1
  • Lu Yue
    • 1
  1. 1.Department of Oncology, Affiliated Hospital of Medical CollegeQingdao UniversityQingdaoChina
  2. 2.Department of RadiotherapyYantai Yuhuangding Hospital Affiliated to Medical College of Qingdao UniversityYantaiChina
  3. 3.Central Laboratory, Affiliated Hospital of Medical CollegeQingdao UniversityQingdaoChina
  4. 4.Department of OncologyYantai Yuhuangding Hospital Affiliated to Medical College of Qingdao UniversityYantaiChina

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