Medical Oncology

, 30:723 | Cite as

Clinical significance of serum soluble interleukin-2 receptor-α in extranodal natural killer/T-cell lymphoma (ENKTL): a predictive biomarker for treatment efficacy and valuable prognostic factor

  • Wang Liang
  • Liao Ding-zhun
  • Zhang Jing
  • Xia Zhong-jun
  • Peng Xiong-wen
  • Lu Yue
Original Paper


Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is an aggressive disease, and no standard treatment and validated prognostic model were established. Serum sIL-2Rα levels were measured in 94 ENKTL patients to evaluate its relationship with clinical features, treatment response, and prognosis. Serum sIL-2Rα level was 2964 ± 1613.6 ng/L in ENKTL patients, higher than in normal healthy controls (p < 0.05). Using median level (2508.5 ng/L) as cutoff, patients were divided into higher- and lower-level group (N = 47 for each). The complete remission and overall remission rate were significantly higher in lower-level group (p < 0.05). After a median follow-up time of 22.0 months, 2-year overall survival and progression-free survival rates were 60.0 and 53.0 %, respectively. Lower sIL-2Rα level significantly correlated with better progression-free survival (PFS) and overall survival (OS) (p = 0.001 and 0.002, respectively). IPI score and treatment responses after 2 cycles of chemotherapy significantly correlated with PFS and OS (p < 0.05). In a multivariate Cox regression model that included IPI score, treatment responses, and sIL-2Rα level, all three parameters were independent prognostic factors for OS (p = 0.043, 0.001, and 0.025, respectively), and the last two parameters were also independent factors for PFS (p = 0.005 and 0.005, respectively). Elevated serum sIL-2Rα level was related to poor responses to treatments and can be used as a valuable biomarker for disease activity. Moreover, serum sIL-2Rα was an independent prognostic factor for both OS and PFS. These results need to be validated in prospective trials and may support the incorporation of anti-CD25 targeted therapy into the treatment realm of ENKTL.


Extranodal natural killer/T-cell lymphoma Soluble interleukin-2 receptor CD25 Prognosis Targeted therapy 



We thank all of the physicians at Sun Yat-sen University Cancer Center for allowing us to include their patients. We also appreciate the cooperation of all the pathologists at Sun Yat-sen University Cancer Center for their support. This work received grant support from Young Teachers’ Cultivation Project of Sun Yat-sen University (No. 12ykpy54) and National Natural Science Foundation of China (No. 81272620).

Conflict of interest



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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Wang Liang
    • 1
    • 3
  • Liao Ding-zhun
    • 2
    • 3
  • Zhang Jing
    • 1
    • 3
  • Xia Zhong-jun
    • 1
    • 3
  • Peng Xiong-wen
    • 1
    • 3
  • Lu Yue
    • 1
    • 3
  1. 1.Department of Hematological OncologySun Yat-sen University Cancer CenterGuangzhouPeople’s Republic of China
  2. 2.Department of PathologySun Yat-sen University Cancer CenterGuangzhouPeople’s Republic of China
  3. 3.State Key Laboratory of Oncology in South ChinaGuangzhouPeople’s Republic of China

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