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Medical Oncology

, 30:666 | Cite as

The basic helix-loop-helix (bHLH) proteins in breast cancer progression

  • Nuzhat N. Kabir
  • Lars Rönnstrand
  • Julhash U. Kazi
Letter to the Editor

The basic helix-loop-helix (bHLH) proteins are the major transcription factors acting as transcriptional enhancers or inhibitors of various genes through binding to the canonical E-box sequence. The bHLH proteins are highly conserved in both vertebrates and invertebrates. The bHLH domain is approximately 60 amino acids in length consisting of a DNA-binding basic region followed by two alpha-helices separated by a variable loop. The DNA-binding basic region associates with the hexanucleotide E-box sequence. The human genome contains 121 bHLH genes which regulate various cellular processes including embryonic development [1, 2]. Many of them are involved in cell proliferation, differentiation and oncogenesis, as well as apoptosis. For example, MyoD and NeuroD family bHLH proteins contribute to myogenesis, neurogenic differentiation and pancreatic development, while Myc family bHLH proteins are directly involved in cell differentiation, proliferation and oncogenesis [3].

The bHLH proteins...

Keywords

Breast Cancer Principal Component Analysis Analysis bHLH Protein bHLH Gene NCBI Gene Expression Omnibus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

12032_2013_666_MOESM1_ESM.pdf (6.4 mb)
Supplementary material 1 (PDF 6571 kb)

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Nuzhat N. Kabir
    • 1
  • Lars Rönnstrand
    • 2
  • Julhash U. Kazi
    • 1
    • 2
  1. 1.Laboratory of Computational BiochemistryKN Biomedical Research InstituteBarisalBangladesh
  2. 2.Experimental Clinical Chemistry, Department of Laboratory Medicine, Wallenberg LaboratoryLund University, Skåne University HospitalMalmöSweden

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