Medical Oncology

, 30:632 | Cite as

Decreased Kruppel-like factor 4 (KLF4) expression may correlate with poor survival in gastric adenocarcinoma

  • Li-Sung Hsu
  • Chien-Pin Chan
  • Chih-Jung Chen
  • Shu-Hui Lin
  • Ming-Tsung Lai
  • Jeng-Dong Hsu
  • Kun-Tu YehEmail author
  • Maw-Soan SoonEmail author
Original Paper


Kruppel-like factors (KLFs) play either anti- or pro-proliferation roles in different human cancers. Here, we investigated the expression of KLF4 in gastric cancers and its correlation with clinicopathological parameters and overall survival. KLF4 expression was measured in 118 surgical specimens by immunohistochemical microarray assay. No association of cytoplasmic KLF4 expression with gender, TNM status, stage, survival, and pathological type was found. Using Kaplan–Meier analysis, significantly higher overall survival rate was observed in patients with high cytoplasmic KLF4 expression compared to low cytoplasmic KLF4 expression. Univariate analysis revealed that cytoplasmic KLF4 expression, grade, histological type, lymph node metastasis, and stages were correlated to longer overall survival. Our results suggest that KLF4 may play an anti-oncogenic role in gastric tumorigenesis.


Kruppel-like factor 4 Gastric adenocarcinoma Immunohistochemical stain 



This work was supported by Grant: 99-CCH-IRP-09 from Changhua Christian Hospital.

Conflict of interests

We declare that we did not have conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Li-Sung Hsu
    • 1
    • 2
  • Chien-Pin Chan
    • 3
  • Chih-Jung Chen
    • 4
    • 5
  • Shu-Hui Lin
    • 4
    • 5
  • Ming-Tsung Lai
    • 6
    • 7
  • Jeng-Dong Hsu
    • 6
    • 7
  • Kun-Tu Yeh
    • 4
    • 6
    Email author
  • Maw-Soan Soon
    • 8
    • 9
    • 10
    Email author
  1. 1.Institute of Biochemistry and BiotechnologyChung Shan Medical UniversityTaichungTaiwan
  2. 2.Clinical LaboratoryChung Shan Medical University HospitalTaichungTaiwan
  3. 3.Department of General SurgeryChanghua Christian HospitalChanghuaTaiwan
  4. 4.Department of PathologyChanghua Christian HospitalChanghuaTaiwan
  5. 5.Department of Medical TechnologyJen-Teh Junior College of Medicine, Nursing and ManagementMiaoliTaiwan
  6. 6.Department of Pathology, School of MedicineChung Shan Medical UniversityTaichungTaiwan
  7. 7.Department of PathologyChung Shan Medical University HospitalTaichungTaiwan
  8. 8.Department of GastroenterologyChanghua Christian HospitalChanghuaTaiwan
  9. 9.Graduate Institute of BiotechnologyNational Changhua University of EducationChanghuaTaiwan
  10. 10.General Education CenterChienkuo Technology UniversityChanghuaTaiwan

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