Medical Oncology

, 30:604 | Cite as

UGT1A1*6/*28 polymorphisms could predict irinotecan-induced severe neutropenia not diarrhea in Chinese colorectal cancer patients

  • Jing Gao
  • Jun Zhou
  • Yanyan Li
  • Ming Lu
  • Ru Jia
  • Lin Shen
Original Paper

Abstract

The aim of this study was to investigate the associations between UDP-glucuronosyltransferase (UGT) 1A1 polymorphisms and irinotecan-induced toxicities in Chinese advanced colorectal cancer patients. The genotypes of UGT1A1*6 and UGT1A1*28 were analyzed by PCR amplification and Sanger sequencing in 276 advanced colorectal cancer patients receiving irinotecan-containing chemotherapy. The influences of UGT1A1*6/*28 polymorphisms on severe diarrhea and neutropenia were analyzed. The overall incidence of UGT1A1*6 and UGT1A1*28 variants was 35.5 % (GA: 28.6 %; AA: 6.9 %) and 21.0 % (TA6/TA7: 19.9 %; TA7/TA7: 1.1 %) in our cohort, respectively. A total of 16 patients (5.8 %, 16/276) had severe diarrhea and 56 patients (20.3 %, 56/276) had severe neutropenia. Neither UGT1A1*6 nor UGT1A1*28 variants were associated with severe diarrhea; however, either UGT1A1*6 (P = 0.001) or UGT1A1*28 (P = 0.029) variants were significantly associated with severe neutropenia. No differences were found between severe toxicities and clinical response in this study. Compared to western countries, Chinese patients had a distinct frequency of UGT1A1*6 or UGT1A1*28 genotypes. Both UGT1A1*6 and UGT1A1*28 variants were closely associated with irinotecan-induced severe neutropenia, but not diarrhea.

Keywords

UGT1A1 Polymorphism Irinotecan Diarrhea Neutropenia 

Notes

Acknowledgments

This work was supported by National Natural Science Foundation of China (No. 81172110), National High Technology Research and Development Program (No. 2006AA 02A 402-B02, 2012AA 02A 504). We thank Dr. Jiping Yue (Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France) for critical reading of this manuscript.

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jing Gao
    • 1
  • Jun Zhou
    • 1
  • Yanyan Li
    • 1
  • Ming Lu
    • 1
  • Ru Jia
    • 1
  • Lin Shen
    • 1
  1. 1.Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education)Peking University, Cancer Hospital & InstituteBeijingChina

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