Advertisement

Medical Oncology

, 30:462 | Cite as

FLT3 mutations in patients with childhood acute lymphoblastic leukemia (ALL)

  • Nuzhat N. Kabir
  • Lars Rönnstrand
  • Julhash U. Kazi
Letter to the Editor

The type III receptor tyrosine kinase FLT3 is of importance in hematopoiesis. FLT3 is a frequently mutated gene in acute myeloid leukemia (AML) as well as prognostic marker. The most common mutation that occurs in patients includes internal tandem duplication (ITD) in the juxtamembrane domain. Point mutations in the kinase domain are also identified in many patients. These mutations result in constitutive activation of receptor as well as uncontrolled activation of survival pathways. Although 30 % of AML patients carry a mutation in FLT3 [2], its expression is not limited to only those patients. It has also been found to be expressed in acute lymphoblastic leukemia (ALL) and several studies identified FLT3 mutations in a portion of ALL patients. This study will identify possible correlation in between FLT3 and childhood ALL patients.

With the search criteria depicted in Fig.  1a, we retrieved 12 references that included 1,213 childhood ALL patients with 76 patients (6.3 %) carrying...

Keywords

Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Lymphoblastic Leukemia Acute Myeloid Leukemia Patient Common Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

12032_2013_462_MOESM1_ESM.pdf (19 kb)
Supplementary material 1 (PDF 19 kb)

References

  1. 1.
    Armstrong SA, Mabon ME, Silverman LB, Li A, Gribben JG, Fox EA, Sallan SE, Korsmeyer SJ. FLT3 mutations in childhood acute lymphoblastic leukemia. Blood. 2004;103:3544–6.PubMedCrossRefGoogle Scholar
  2. 2.
    Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532–42.PubMedCrossRefGoogle Scholar
  3. 3.
    Taketani T, Taki T, Sugita K, Furuichi Y, Ishii E, Hanada R, Tsuchida M, Sugita K, Ida K, Hayashi Y. FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. Blood. 2004;103:1085–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Nuzhat N. Kabir
    • 1
  • Lars Rönnstrand
    • 2
  • Julhash U. Kazi
    • 1
    • 2
  1. 1.Laboratory of Computational BiochemistryKN Biomedical Research InstituteBarisalBangladesh
  2. 2.Experimental Clinical Chemistry, Department of Laboratory MedicineLund UniversityMalmöSweden

Personalised recommendations