Medical Oncology

, 30:448 | Cite as

Selective mutation in ATP-binding site reduces affinity of drug to the kinase: a possible mechanism of chemo-resistance

  • Nuzhat N. Kabir
  • Julhash U. KaziEmail author
Letter to the Editor


Kinase Domain Important Residue Selective Mutation Individual Residue Eukaryotic Protein Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest

The authors declare no conflict of interest.

Supplementary material

12032_2012_448_MOESM1_ESM.doc (86 kb)
Supplementary material 1 (DOC 85 kb)


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    Williams AB, Nguyen B, Li L, Brown P, Levis M, Leahy D et al. Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, UK. 2012. doi: 10.1038/leu.2012.191.
  2. 2.
    Kazi JU. The mechanism of protein kinase C regulation. Front Biol. 2011;6:328–36.Google Scholar
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    Smith CC, Wang Q, Chin CS, Salerno S, Damon LE, Levis MJ, et al. Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature. 2012;485(7397):260–3. doi: 10.1038/nature11016.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Laboratory of Computational BiochemistryKN Biomedical Research InstituteBarisalBangladesh
  2. 2.Experimental Clinical Chemistry, Department of Laboratory MedicineLund UniversityMalmöSweden

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