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Medical Oncology

, 30:374 | Cite as

Relation between vascular patterns visualized by narrow band imaging (NBI) videobronchoscopy and histological type of lung cancer

  • Bojan ZaricEmail author
  • Branislav Perin
  • Vladimir Stojsic
  • Vladimir Carapic
  • Zivka Eri
  • Milana Panjkovic
  • Ilija Andrijevic
  • Jovan Matijasevic
Original Paper

Abstract

Narrow Band Imaging (NBI) videobronchoscopy is a new technique for visualization of microvascular changes in bronchial mucosa. The primary aim of this study was to evaluate relation between vascular patterns visualized by NBI and histology of lung cancer. We prospectively evaluated 65 patients with suspected lung cancer scheduled for bronchoscopy. NBI followed conventional WL videobronchoscopy. After identification of endoscopically visible tumor, NBI was used to determine predominant type of pathological vascular pattern (dotted, tortuous, abrupt-ending blood vessels—Shibuya descriptors). All the lesions were biopsied and histologically confirmed. There were 81.5 % male and 18.5 % female patients evaluated in the study. Lung cancer was confirmed in all patients; 63.1 % were diagnosed with squamous cell lung cancer (SCC), 24.6 % had adenocarcinoma, 9.2 % had small-cell (SCLC) and 3.1 % large-cell lung cancer (LC). Dotted blood vessels were significantly (p < 0.000) associated with adenocarcinoma, identified in 68.4 % adenocarcinoma and 31.6 % SCC. Tortuous blood vessels were identified in 72 % SCC, 8 % adenocarcinoma, 12 % SCLC and 8 % of LC. Tortuous blood vessels were significantly (p < 0.000) associated with SCC. Abrupt-ending vessels were identified in 81 % SCC, 14.3 % SCLC and 4.8 % adenocarcinoma and were significantly associated (p < 0.000) with SCC. Dotted visual pattern of blood vessels identified during NBI videobronchoscopy is highly suggesting adenocarcinoma histology of lung cancer. Tortuous and abrupt-ending blood vessels visualized under NBI videobronchoscopy significantly suggest squamous cell histology of lung cancer. Large-scale studies should be designed in order to determine true relation between visual appearance and histology in lung cancer.

Keywords

Bronchoscopy Lung cancer Narrow band imaging Precancerous lesions Videobronchoscopy 

Notes

Acknowledgments

The study was supported by the grant of the Serbian Ministry for Science and Technology, grant number 175056.

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Bojan Zaric
    • 1
    Email author
  • Branislav Perin
    • 1
  • Vladimir Stojsic
    • 1
  • Vladimir Carapic
    • 1
  • Zivka Eri
    • 1
  • Milana Panjkovic
    • 1
  • Ilija Andrijevic
    • 2
  • Jovan Matijasevic
    • 2
  1. 1.Department for Interventional Pulmonology, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for Pulmonary OncologyUniversity of Novi SadSremska KamenicaSerbia
  2. 2.Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for Urgent PulmonologyUniversity of Novi SadSremska KamenicaSerbia

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