Medical Oncology

, Volume 29, Issue 1, pp 260–262 | Cite as

Central nervous system relapse in CD56+, FLT3/ITD+ promyelocytic leukemia

  • N. Colovic
  • D. Tomin
  • A. Vidovic
  • N. Tosic
  • H. D. Atkinson
  • Milica D. Colovic
Case Report


Central nervous system (CNS) involvement in acute promyelocytic leukemia (APL) is rare and tends to be seen mostly following treatment with all-trans retinoic acid (ATRA), due to prolonged patient survival and poor penetration of the drug in the CNS. At least 10% of extramedullary relapses in APL involve the CNS, and associated factors include an increased age, the BCR isoform, the development of differentiation syndrome, a high white cell count at presentation and hemorrhage into the CNS during induction therapy. We present the case of a patient with high-risk APL, CD56+, CD2+ in whom a CNS relapse was diagnosed through the presence of a PML/RARα rearrangement on PCR of the cerebrospinal fluid (CSF).


Acute Promyelocytic Leukemia Bone Marrow Aspirate Idarubicin Central Nervous System Relapse Elevated White Blood Cell Count 
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This study is supported by grant No. 41004 from the Ministry of Science and the Environmental Protection of the Republic of Serbia.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • N. Colovic
    • 1
    • 2
  • D. Tomin
    • 1
    • 2
  • A. Vidovic
    • 1
    • 2
  • N. Tosic
    • 3
  • H. D. Atkinson
    • 4
  • Milica D. Colovic
    • 1
  1. 1.Institute of Hematology, Clinical Center for SerbiaBelgradeSerbia
  2. 2.Medical FacultyUniversity of Belgrade School of MedicineBelgradeSerbia
  3. 3.Laboratory for Molecular HematologyInstitute of Molecular Genetics and Genetic EngineeringBelgradeSerbia
  4. 4.North Middlesex University HospitalLondonUK

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