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Medical Oncology

, Volume 29, Issue 3, pp 1581–1585 | Cite as

GGCn polymorphism of eRF3a/GSPT1 gene and breast cancer susceptibility

  • Mahboobe Miri
  • Simin Hemati
  • Foruzan Safari
  • Manoochehr TavassoliEmail author
Original Paper

Abstract

The significance of translation regulatory factors in elevating the risk of cancer has been recently recognized. Eukaryotic release factor 3a (eRF3a) is a translation termination protein that is encoded by G1 to S phase transition 1 gene (GSPT1). The eRF3a/GSPT1 exon 1 contains a trinucleotide GGC repeat coding for a polyglycine expansion in the N-terminal of the protein. In the present study, we determined the allelic length of the GGCn repeat in the eRF3a gene in 250 women with breast cancer and 250 age-matched controls. Our results show that the presence of the longer allele, 12-GGC, is correlated with threefold increased risk of breast cancer development. Our findings also suggest that women who are homozygous for 7-GGC allele are possibly at higher risk of developing breast cancer, especially before the age of 50. No significant effect of the allelic length of eRF3a/GSPT1 polymorphism on inheritance or the grade of this disease was observed.

Keywords

eRF3a/GSPT1 GGC repeat Microsatellite Breast cancer 

Notes

Acknowledgments

The authors wish to thank all patients who contributed to this investigation and Professor Farzin Farzaneh (Kings College London) for valuable suggestions and critical reading of this manuscript. This work was supported by University of Isfahan.

Conflicts of interest

The authors report no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Mahboobe Miri
    • 1
  • Simin Hemati
    • 2
  • Foruzan Safari
    • 1
  • Manoochehr Tavassoli
    • 1
    Email author
  1. 1.Department of Biology, Faculty of SciencesUniversity of IsfahanIsfahanIran
  2. 2.Radiation Oncology DepartmentIsfahan University of Medical SciencesIsfahanIran

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