GGCn polymorphism of eRF3a/GSPT1 gene and breast cancer susceptibility
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The significance of translation regulatory factors in elevating the risk of cancer has been recently recognized. Eukaryotic release factor 3a (eRF3a) is a translation termination protein that is encoded by G1 to S phase transition 1 gene (GSPT1). The eRF3a/GSPT1 exon 1 contains a trinucleotide GGC repeat coding for a polyglycine expansion in the N-terminal of the protein. In the present study, we determined the allelic length of the GGCn repeat in the eRF3a gene in 250 women with breast cancer and 250 age-matched controls. Our results show that the presence of the longer allele, 12-GGC, is correlated with threefold increased risk of breast cancer development. Our findings also suggest that women who are homozygous for 7-GGC allele are possibly at higher risk of developing breast cancer, especially before the age of 50. No significant effect of the allelic length of eRF3a/GSPT1 polymorphism on inheritance or the grade of this disease was observed.
KeywordseRF3a/GSPT1 GGC repeat Microsatellite Breast cancer
The authors wish to thank all patients who contributed to this investigation and Professor Farzin Farzaneh (Kings College London) for valuable suggestions and critical reading of this manuscript. This work was supported by University of Isfahan.
Conflicts of interest
The authors report no conflict of interest.