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Medical Oncology

, Volume 28, Issue 4, pp 1054–1057 | Cite as

Down-regulation of miR-126 expression in colorectal cancer and its clinical significance

  • Xiang-Min Li
  • Ai-Min Wang
  • Juan Zhang
  • Hong Yi
Original Paper

Abstract

MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-126 in colorectal cancers are unclear. In this study, we compared the expression of miR-126 between colorectal cancer tissues and non-tumor tissues. The expression levels of miR-126 in colorectal cancer tissues were significantly lower than those in non-tumor tissues, and miR-126 overexpression inhibited the growth of colorectal cancer cells. This new information may help to clarify the molecular mechanisms involved in colorectal carcinogenesis and to indicate that miR-126 may be a novel suppressive microRNA and help to differentiate between malignant and normal colorectal tissue.

Keywords

miR-126 Colorectal cancer Carcinogenesis Molecular marker 

Abbreviations

CRC

Colorectal cancer

TNM

Tumor-node-metastasis

miRNAs

microRNAs

CEA

Carcinoembryonic antigen

Notes

Acknowledgments

The authors thank Dr. Yanhong Zhou for guidance in data analysis.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Xiang-Min Li
    • 1
  • Ai-Min Wang
    • 1
  • Juan Zhang
    • 1
  • Hong Yi
    • 2
  1. 1.Emergency Department of Xiangya HospitalCentral South UniversityChangshaChina
  2. 2.Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya HospitalCentral South UniversityChangshaChina

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