Down-regulation of miR-126 expression in colorectal cancer and its clinical significance
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MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-126 in colorectal cancers are unclear. In this study, we compared the expression of miR-126 between colorectal cancer tissues and non-tumor tissues. The expression levels of miR-126 in colorectal cancer tissues were significantly lower than those in non-tumor tissues, and miR-126 overexpression inhibited the growth of colorectal cancer cells. This new information may help to clarify the molecular mechanisms involved in colorectal carcinogenesis and to indicate that miR-126 may be a novel suppressive microRNA and help to differentiate between malignant and normal colorectal tissue.
KeywordsmiR-126 Colorectal cancer Carcinogenesis Molecular marker
The authors thank Dr. Yanhong Zhou for guidance in data analysis.
- 4.Esquela-Kerscher A, Slack FJ. Oncomirs—microRNAs with a role in cancer. Nat Rev. 2006;6:259–69.Google Scholar
- 9.Sobin LH, Wittekind CH, editors. TNM classification of malignant tumors. 5th ed. International Union Against Cancer (UICC). New York: Wiley; 1997. p. 59–62.Google Scholar