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Medical Oncology

, Volume 28, Issue 4, pp 1169–1175 | Cite as

Polymorphism of vascular endothelial growth factor 2578C/A with cancer risk: evidence from 11263 subjects

  • Chao Cao
  • Tao Ying
  • Jing-Jing Fang
  • Shi-Fang Sun
  • Dan Lv
  • Zhong-Bo Chen
  • Hong-Ying Ma
  • Yi-Ming Yu
  • Qun-Li Ding
  • Li-Hua Shu
  • Zai-Chun Deng
Original Paper

Abstract

Published data on the association between vascular endothelial growth factor (VEGF) –2578C/A polymorphism and cancer risk is inconclusive. To derive a more precise estimation of association between VEGF –2578C/A polymorphism and the risk of cancer, we performed a meta-analysis of 5415 cancer cases and 5848 controls from 16 published case–control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Our meta-analysis indicated that VEGF –2578C/A polymorphism was associated with the risk of colorectal cancer under homozygote comparison (OR = 0.70, 95% CI = 0.53–0.92), dominant model (OR = 0.72, 95% CI = 0.57–0.92), and recessive model (OR = 0.82, 95% CI = 0.67–1.01), although no evidence of association between VEGF –2578C/A polymorphism and cancer risk was observed as we compared in the pooled analyses (homozygote comparison: OR = 0.97, 95% CI = 0.81–1.16). More studies are needed to detect VEGF –2578C/A polymorphism and its association with cancer in different ethnic populations incorporated with environmental exposures in the susceptibility of different kinds of cancer.

Keywords

VEGF Polymorphism Cancer Susceptibility Meta-analysis 

Notes

Acknowledgments

We are extremely thankful to Dr. Da-Xiong Zeng of Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, for his review and scientific editing of the manuscript.

Conflict of Interest Statement

None declared.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Chao Cao
    • 1
  • Tao Ying
    • 1
  • Jing-Jing Fang
    • 1
  • Shi-Fang Sun
    • 1
  • Dan Lv
    • 1
  • Zhong-Bo Chen
    • 1
  • Hong-Ying Ma
    • 1
  • Yi-Ming Yu
    • 1
  • Qun-Li Ding
    • 1
  • Li-Hua Shu
    • 1
  • Zai-Chun Deng
    • 1
  1. 1.Department of Respiratory Medicine, The Affiliated Hospital of School of MedicineNingbo UniversityNingboChina

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