Advertisement

Medical Oncology

, Volume 28, Issue 4, pp 1389–1394 | Cite as

Lingual metastasis as an initial presentation of renal cell carcinoma

  • Izumi Yoshitomi
  • Goro Kawasaki
  • Akio Mizuno
  • Masaharu Nishikido
  • Tomayoshi Hayashi
  • Shuichi Fujita
  • Tohru Ikeda
Original Paper

Abstract

Distant metastasis of malignant neoplasm to the oral soft tissue is extremely rare. We report a case of renal cell carcinoma (RCC) metastasizing to the tongue. A 47-year-old man visited our hospital with chief complaint of a lump on the middle third of the dorsum of his tongue and the lesion fell off from the tongue. Although histopathological diagnosis of the mass was granuloma teleangiectaticum, similar nodule reappeared in the same area 2 weeks later. The second lesion was composed of granuloma teleangiectaticum and aggregation of neoplastic clear cells in ductal arrangement. The clear cells were immunohistochemically positive for EMA and CD10. The abdominal CT scan revealed a 5.5 cm mass in the left kidney, suggesting RCC. Thus, the lingual lesion was consistent with metastatic RCC. There has been no recurrence for 2 years after the radical nephrectomy and local excision of the tongue.

Keywords

Renal cell carcinoma Lingual metastasis CD10 

Notes

Acknowledgments

We thank the staff of the Department of Radiology and Cancer Biology, Nagasaki University Graduate School of Biomedical Sciences.

References

  1. 1.
    Pritchyk KM, et al. Metastatic renal cell carcinoma to the head and neck. Laryngoscope. 2002;112(9):1598–602.PubMedCrossRefGoogle Scholar
  2. 2.
    Zegarelli DJ, et al. Metastatic tumor to the tongue. Report of twelve cases. Oral Surg Oral Med Oral Pathol. 1973;35(2):202–11.PubMedCrossRefGoogle Scholar
  3. 3.
    Pires FR, et al. Metastatic renal cell carcinoma to the oral cavity and clear cell mucoepidermoid carcinoma: comparative clinicopathologic and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(4):e22–7.PubMedCrossRefGoogle Scholar
  4. 4.
    Yamamoto D, et al. Metastatic gastric tumor from renal cell carcinoma. Gastric Cancer. 2009;12(3):170–3.PubMedCrossRefGoogle Scholar
  5. 5.
    Rivera AL, et al. Useful immunohistochemical markers in differentiating hemangioblastoma versus metastatic renal cell carcinoma. Neuropathology. 30 March 2010 [Epub ahead of print]Google Scholar
  6. 6.
    Friedlander AH, Singer R. Renal adenocarcinoma of the kidney with metastasis to the tongue. J Am Dent Assoc. 1978;97(6):989–91.PubMedGoogle Scholar
  7. 7.
    Sgouras ND, et al. An unusual presentation of a metastatic hypernephroma to the frontonasal region. Ann Plast Surg. 1995;34(6):653–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Gottlieb MD, Roland JT Jr. Paradoxical spread of renal cell carcinoma to the head and neck. Laryngoscope. 1998;108(9):1301–5.PubMedCrossRefGoogle Scholar
  9. 9.
    Boles R, Cerny J. Head and neck metastases from renal carcinomas. Mich Med. 1971;70(16):616–8.PubMedGoogle Scholar
  10. 10.
    Ol’shevskii VA, Fofanov VV, Arifmetikova TN. Metastasis of clear-cell cancer of the kidney to the tongue. Arkh Patol. 1984;46(10):85–6.PubMedGoogle Scholar
  11. 11.
    Azam F, Abubakerr M, Gollins S. Tongue metastasis as an initial presentation of renal cell carcinoma: a case report and literature review. J Med Case Reports. 2008;2:249.PubMedCrossRefGoogle Scholar
  12. 12.
    Cheng ET, Greene D, Koch RJ. Metastatic renal cell carcinoma to the nose. Otolaryngol Head Neck Surg. 2000;122(3):464.PubMedCrossRefGoogle Scholar
  13. 13.
    Fukuda M, et al. A case series of 9 tumors metastatic to the oral and maxillofacial region. J Oral Maxillofac Surg. 2002;60(8):942–4.PubMedCrossRefGoogle Scholar
  14. 14.
    Marioni G, et al. Uncommon metastatic site of renal adenocarcinoma: the oral tongue. Acta Otolaryngol. 2004;124(2):197–201.PubMedCrossRefGoogle Scholar
  15. 15.
    Simo R, et al. Metastatic renal cell carcinoma to the nose and paranasal sinuses. Head Neck. 2000;22(7):722–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Shibayama T, et al. Disappearance of metastatic renal cell carcinoma to the base of the tongue after systemic administration of interferon-alpha. Eur Urol. 1993;24(2):297–9.PubMedGoogle Scholar
  17. 17.
    Basso M, Cassano A, Barone C. A survey of therapy for advanced renal cell carcinoma. Urol Oncol. 2009;28(2):121–33.PubMedCrossRefGoogle Scholar
  18. 18.
    Will TA, Agarwal N, Petruzzelli GJ. Oral cavity metastasis of renal cell carcinoma: a case report. J Med Case Reports. 2008;2:313.PubMedCrossRefGoogle Scholar
  19. 19.
    Campbell SC, Novick AC, Bukowski RM. Renal tumors. In: Wein AJ, editor. Campbell-Walsh urology, vol. 2. 9th ed. Philadelphia: Saunders Elsevier; 2007. p. 1582–632.Google Scholar
  20. 20.
    Satomi Y, et al. Three cases of hypernephroma metastasis in the otorhinopharyngolaryngeal region (parotid gland, nasal cavity, tongue and gingiva). Jpn J Clin Urol. 1974;28(8):611–6.Google Scholar
  21. 21.
    Fitzgerald RH, et al. Renal cell carcinoma involving oral soft tissues. J Oral Maxillofac Surg. 1982;40(9):604–6.PubMedCrossRefGoogle Scholar
  22. 22.
    Kitao K, et al. Metastatic Gravitz tumor of the base of tongue. A case report. Jibi Inkoka. 1986;58(1):67–70.Google Scholar
  23. 23.
    Inai T, et al. A renal cell carcinoma with metastatis to the tongue. Acta Urol Jpn. 1987;33(8):1240–3.Google Scholar
  24. 24.
    Matsumoto A, Iio S. Metastasis of renal cell carcinoma to the tongue: a case report. Nishinihon J Urol. 1987;49:1147–9.Google Scholar
  25. 25.
    Kapoor VK, et al. Renal cell carcinoma metastatic to the tongue. J Indian Med Assoc. 1987;85(4):119–20.PubMedGoogle Scholar
  26. 26.
    Madison JF, et al. Pathologic quiz case 2. Arch Otolaryngol Head Neck Surg. 1988;114(5):570–3.PubMedGoogle Scholar
  27. 27.
    Ishikawa J, et al. Renal cell carcinoma metastatic to the tongue: a case report. Acta Urol Jpn. 1991;37(3):263–5.Google Scholar
  28. 28.
    Okabe Y, et al. View from beneath: pathology in focus. Renal cell carcinoma metastasis to the tongue. J Laryngol Otol. 1992;106(3);282–4.PubMedCrossRefGoogle Scholar
  29. 29.
    Ziyada WF, et al. Expectorated tissue leading to diagnosis of renal adenocarcinoma. J Laryngol Otol. 1994;108(12):1108–10.PubMedCrossRefGoogle Scholar
  30. 30.
    Airoldi M, et al. Head and neck metastases of renal cancer after nephrectomy: a report of 2 cases. Tumori. 1996;81(3):213–4.Google Scholar
  31. 31.
    Aguirre A, Rinaggio J. Lingual metastasis of renal cell carcinoma. J Oral Maxillofac Surg. 1996;54(3):344–6.PubMedCrossRefGoogle Scholar
  32. 32.
    Konya E, et al. Two cases of renal cell carcinoma detected by metastasis to another organ. Hinyokika Kiyo. 1997;43(9):647–50.PubMedGoogle Scholar
  33. 33.
    Tomita T, et al. Palliative radiotherapy for lingual metastasis of renal cell carcinoma. Auris Nasus Larynx. 1998;25(2):209–14.PubMedCrossRefGoogle Scholar
  34. 34.
    Navarro F, et al. Metastatic renal cell carcinoma to the head and neck area. Tumori. 2000;86(1):88–90.PubMedGoogle Scholar
  35. 35.
    Goel MC, et al. Lingual metastasis from renal cell carcinoma management and review of the literature. Urol Int. 2003;71(4):418–21.PubMedCrossRefGoogle Scholar
  36. 36.
    Lang EE. A case of renal cell carcinoma metastatic to the nose and tongue. Ear Nose Throat J. 2003;82(5):382–3.PubMedGoogle Scholar
  37. 37.
    Kyan A, et al. Renal cell carcinoma to the base of tongue: a case report. Hinyokika Kiyo. 2004;50(11):791–3. PubMedGoogle Scholar
  38. 38.
    Tachi T, et al. Renal cell carcinoma with metastasis to the tongue. Pract otol (Kyoto). 2005;98(7):543–6.Google Scholar
  39. 39.
    Torres-Carranza E, et al. Airway obstruction due to metastatic renal cell carcinoma to the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):E76–78.PubMedCrossRefGoogle Scholar
  40. 40.
    Cochrane TJ. Renal cell carcinoma: a rare metastasis to the tongue—a case report. Dent Update. 2006;33(3):186–7.Google Scholar
  41. 41.
    Tanaka Y, et al. A case of renal carcinoma metastatic to the tongue. Pract otol (Kyoto). 2007;100(5):375–8.Google Scholar
  42. 42.
    Basely M, et al. A rare presentation of metastatic renal clear cell carcinoma to the tongue seen on FDG PET. Clin Nucl Med. 2009;34(9):566–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Izumi Yoshitomi
    • 1
  • Goro Kawasaki
    • 1
  • Akio Mizuno
    • 1
  • Masaharu Nishikido
    • 2
  • Tomayoshi Hayashi
    • 3
  • Shuichi Fujita
    • 4
  • Tohru Ikeda
    • 4
  1. 1.Department of Oral and Maxillofacial Surgery, Unit of Translational Medicine, Sciences, Course of Medical and Dental SciencesNagasaki University Graduate School of Biomedical SciencesNagasakiJapan
  2. 2.Department of Nephro-Urology, Unit of Translational Medicine, Sciences, Course of Medical and Dental SciencesNagasaki University Graduate School of Biomedical SciencesNagasakiJapan
  3. 3.Department of PathologyNagasaki University HospitalNagasakiJapan
  4. 4.Department of Oral Pathology and Bone Metabolism, Unit of Basic Medical Sciences, Course of Medical and Dental SciencesNagasaki University Graduate School of Biomedical SciencesNagasakiJapan

Personalised recommendations