Medical Oncology

, Volume 28, Issue 4, pp 991–998

Biomarker analysis in patients with advanced gastric cancer treated with S-1 plus cisplatin chemotherapy: orotate phosphoribosyltransferase expression is associated with treatment outcomes

  • In Sil Choi
  • Hye Seung Lee
  • Keun-Wook Lee
  • Haeryoung Kim
  • Ki Hwan Kim
  • Yu Jung Kim
  • Jee Hyun Kim
  • Woo Ho Kim
  • Jong Seok Lee
Original Paper

Abstract

This study was performed to analyze the impact of protein expression related to fluoropyrimidine and cisplatin metabolism (thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, orotate phosphoribosyltransferase [OPRT], excision repair cross-complementation 1, Fanconi anemia complementation group D2, glutathione S-transferase P1, and X-ray repair cross-complementing group 1) on treatment outcomes in patients with metastatic or relapsed gastric cancer (MRGC) receiving S-1/cisplatin chemotherapy. Protein expression was measured by immunohistochemistry (IHC). Of the 43 patients who had received S-1 (80 mg/m2/day; days 1–14) and cisplatin (60 mg/m2; day 1) every 3 weeks and had available tissue blocks, IHC was successfully performed in 41 patients. Patients with high OPRT levels in tumor tissues (IHC score ≥6) had superior progression-free survival (PFS) (23.3 vs. 14.1 weeks [median]) and overall survival (OS) (72.4 vs. 55.4 weeks [median]) to those with low OPRT levels (IHC score ≤5; P-values <.05). Expression levels of other proteins were not predictive of treatment outcomes. In multivariate analysis, both a good performance status and a high OPRT level were independently associated with prolonged PFS and OS. The OPRT expression level may be a good predictive marker in S-1/cisplatin-treated patients with MRGC.

Keywords

S-1 Cisplatin Chemotherapy Gastric cancer Orotate phosphoribosyltransferase Biomarker 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • In Sil Choi
    • 3
  • Hye Seung Lee
    • 2
  • Keun-Wook Lee
    • 1
  • Haeryoung Kim
    • 2
  • Ki Hwan Kim
    • 1
  • Yu Jung Kim
    • 1
  • Jee Hyun Kim
    • 1
  • Woo Ho Kim
    • 4
  • Jong Seok Lee
    • 1
  1. 1.Department of Internal MedicineSeoul National University Bundang Hospital, Seoul National University College of MedicineSeongnam-siKorea
  2. 2.Department of PathologySeoul National University Bundang Hospital, Seoul National University College of MedicineSeongnamKorea
  3. 3.Department of Internal MedicineSeoul Municipal Boramae Hospital, Seoul National University College of MedicineSeoulKorea
  4. 4.Department of PathologySeoul National University Hospital, Seoul National University College of MedicineSeoulKorea

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