Lack of significant association between TGF-β1 -590C/T polymorphism and breast cancer risk: a meta-analysis
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Transforming growth factor β1 (TGF-β1) is a cytokine that plays an important role in the control of cell proliferation and differentiation in breast cancer. The -509C/T polymorphism in the TGF-β1 gene has been implicated in breast cancer risk. However, studies on the association between this polymorphism and breast cancer risk have produced conflicting results. To derive a more precise estimation of the relationship, a meta-analysis of the -509C/T polymorphism (5,825 cases and 7,953 controls) from seven published case–control studies was performed. Our analysis suggests that -509C/T has no association with breast cancer risk when using either dominant [odds ratio (OR) = 1.01, 95% confidence intervals (CI): 0.82–1.24], or recessive models (OR = 0.91, 95% CI: 0.66–1.27), or other genetic models to analyze the data. In ethnic subgroups analysis, -509C/T also did not appear to be a risk factor for breast cancer. However, larger scale primary studies are still required to further evaluate the interaction of TGF-β1 -509C/T polymorphism and breast cancer risk in specific populations.
KeywordsTGF-β1 Breast cancer Polymorphism Meta-analysis
The authors thank Dr. John Kokontis for editorial assistance of the manuscript. This work was supported by National 973 Programs of China grant [2004CB518605 to L.Y.], the National 863 project of China [2006AA020501 to L.Y.],the National Key Sci-Tech Special Project of China [2008ZX10002-020], the Project of the Shanghai Municipal Science and Technology Commission [03dz14086], and the National Natural Science foundation of China [30024001,30771188].
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