Medical Oncology

, 26:365

The angiogenic and prognostic implications of VEGF, Ang-1, Ang-2, and MMP-9 for hepatocellular carcinoma with background of hepatitis B virus

  • Zu-Bing Chen
  • Shi-Qiang Shen
  • You-Ming Ding
  • Wei-Xing Wang
  • Jian-Ping Tao
  • Li-Jian Liang
  • Wen-Jie Hu
Original Paper

DOI: 10.1007/s12032-008-9130-7

Cite this article as:
Chen, ZB., Shen, SQ., Ding, YM. et al. Med Oncol (2009) 26: 365. doi:10.1007/s12032-008-9130-7

Abstract

The objective of this study was to investigate the expressions of angiogenic factors and elucidate their angiogenic and prognostic roles in hepatocellular carcinoma (HCC) with background of hepatitis B virus (HBV). We evaluated microvessel density (MVD) of HCC, and investigated immunohistochemical expression of vascular endothelial growth factor (VEGF), angiopoietins (Ang-1 and Ang-2), and matrix metalloproteinases-9 (MMP-9) in 67 specimens of surgically resected HCC, which were all positive for hepatitis B surface antigen. We investigated the relationship between their expressions and clinicopathological factors or prognosis. The microvessel density (MVD) of tumor tissue and surrounding normal liver tissue was 93.1 ± 43.8/mm2 and 30.4 ± 14.8/mm2, respectively. The MVD of well-differentiated HCC was significantly less than that of poorly differentiated HCC. MVD was positively correlated with VEGF and Ang-2 expression (P = 0.0023 and 0.0265, respectively). There was less tumor recurrence in low Ang-2 and low MMP-9 group than high Ang-2 and/or high MMP-9 group (P = 0.002). In Cox regression model, portal vein thrombus and intrahepatic metastasis was the risk factors of tumor recurrence (P = 0.003 and 0.001, respectively). Our study showed that the expression of VEGF and Ang-2 were positively correlated with MVD. Ang-2 expression and/or MMP-9 expression might be a significant predictive factor for recurrence after resection in HCC patients with the background of HBV.

Keywords

Hepatocellular carcinoma Microvessel density Vascular endothelial growth factor Angiopoietin-2 Matrix-degrading matrix metalloproteinases-9 Angiogenesis 

Copyright information

© Humana Press Inc. 2008

Authors and Affiliations

  • Zu-Bing Chen
    • 1
  • Shi-Qiang Shen
    • 1
  • You-Ming Ding
    • 1
  • Wei-Xing Wang
    • 1
  • Jian-Ping Tao
    • 2
  • Li-Jian Liang
    • 3
  • Wen-Jie Hu
    • 3
  1. 1.Department of General SurgeryRenmin Hospital of Wuhan UniversityWuhanChina
  2. 2.Department of MicrobiologySun-Yat-Sen Medical CollegeGuangzhouChina
  3. 3.Department of Hepatobiliary Surgery, The First Affiliated HospitalSun-Yat-Sen UniversityGuangzhouChina

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