Medical Oncology

, Volume 24, Issue 3, pp 308–311 | Cite as

Pentoxifylline and alpha-tocopherol in prevention of radiation-induced lung toxicity in patients with lung cancer

  • Cem H. Misirlioglu
  • Taciser Demirkasimoglu
  • Bulent Kucukplakci
  • Ergun Sanri
  • Kadri Altundag
Original Article

Abstract

Combined use of pentoxifylline and vitamin E is reported to reduce radiation-induced toxicity in normal tissues at molecular level. We plan to evaluate the role of combined use of pentoxifylline (PTX) and alpha-tocopherol (vitamin E; Vit E) for minimizing radiation-induced lung toxicity. A total of 91 lung cancer patients were randomized. Among them, 44 received PTX (400 mg three times a day orally and Vit E 300 mg twice a day orally during the entire period of radiotherapy. PTX and Vit E were further administered at doses of 400 mg once a day and 300 mg once a day, respectively for 3 months after radiotherapy. A total of 47 patients were assigned as a control group. Radiation related acute and late toxicities are evaluated by radiation RTOG/EORTC toxicity scale. Median age was 59 (range, 41–75). Median follow-up was 13 months (range, 3–28 months). Radiation-induced lung toxicity was more frequent in control group for all phases than in pentoxifylline and alpha-tocopherol group (acute phase, P = 0.042, subacute phase P = 0.0001, late phase P = 0.256). PTX and Vit E combination might be considered especially in patients with lung cancer who receive concurrent chemo-radiotherapy, or have a poor respiratory function tests.

Keywords

Lung cancer Radiation-induced lung toxicity Pentoxifylline Alpha-tocopherol 

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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Cem H. Misirlioglu
    • 1
  • Taciser Demirkasimoglu
    • 1
  • Bulent Kucukplakci
    • 1
  • Ergun Sanri
    • 1
  • Kadri Altundag
    • 2
  1. 1.Department of Radiation OncologyAnkara Oncology HospitalAnkaraTurkey
  2. 2.Department of Medical OncologyHacettepe University Institute of OncologyAnkaraTurkey

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