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Current Progress in Understanding the Structure and Function of Sweet Taste Receptor

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Abstract

The sweet taste receptor, which was identified approximately 20 years ago, mediates sweet taste recognition in humans and other vertebrates. With the development of genomics, metabonomics, structural biology, evolutionary biology, physiology, and neuroscience, as well as technical advances in these areas, our understanding of this important protein has resulted in substantial progress. This article reviews the structure, function, genetics, and evolution of the sweet taste receptor and offers meaningful insights into this G protein–coupled receptor, which may be helpful guidances for personalized feeding, diet, and medicine. Prospective directions for research on sweet taste receptors have also been proposed.

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Funding

This work was supported by the grants from the National Natural Science Foundation of China (31970935, 31271118, and 31501450).

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Correspondence to Bo Liu.

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Yang, L., Cui, M. & Liu, B. Current Progress in Understanding the Structure and Function of Sweet Taste Receptor. J Mol Neurosci 71, 234–244 (2021). https://doi.org/10.1007/s12031-020-01642-4

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  • DOI: https://doi.org/10.1007/s12031-020-01642-4

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