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A Meta-analysis of the Association Between SLC6A3 Gene Polymorphisms and Schizophrenia

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Abstract

The dopamine transporter is coded by the SLC6A3 gene and plays an important role in regulation of the neurotransmitter dopamine. To detect the association between the SLC6A3 gene and the risk of schizophrenia, 31 case-control articles were included in this meta-analysis. There were 23 studies with 40 bp VNTR (3246 cases and 3639 controls), 4 studies with rs40184 (2020 cases and 1674 controls), rs6347 (1317 cases and 1917 controls), rs403636 (2045 cases and 1704 controls), and rs2975226 (849 cases and 904 controls); and 3 studies with rs12516948 (1920 cases and 1569 controls), rs27072 (984 cases and 1015 controls), rs6869645 (1142 cases and 1082 controls), rs37022 (1168 cases and 1091 controls), rs464049 (1169cases and 1096 controls), rs2652511 (707 cases and 714 controls), and rs3756450 (1176 cases and 1096 controls). Pooled, subgroup, and sensitivity analyses were performed, and the results were visualized by forest and funnel plots. In the dominant genetic model, the genotype AA+AT of rs2975226 in the Indian population (Pz = 0, odds ratio [OR] = 3.245, 95% confidence interval [CI] = 1.806–5.831), TT of rs464049 (Pz = 0.002, OR = 1.389, 95% CI = 1.129–1.708), and TT of rs3756450 (Pz = 0.014, OR = 1.251, 95% CI = 1.047–1.495) might be risk factors for schizophrenia. Additionally, no other single nucleotide polymorphisms were observed. These results indicate that more functional studies are warranted.

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Funding

This study was supported by the National Natural Science Foundation of China (No. 81671872).

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Bao-jie Wang and Mei Ding designed the study and wrote the protocol. Feng-ling Xu managed the literature search, and Xue Wu, Yong-ping Liu, and Xi Xia checked the literature. Feng-ling Xu performed the analyses. The first draft of the manuscript was written by Feng-ling Xu and revised by Jun Yao.

Correspondence to Jun Yao or Bao-jie Wang.

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Xu, F., Ding, M., Wu, X. et al. A Meta-analysis of the Association Between SLC6A3 Gene Polymorphisms and Schizophrenia. J Mol Neurosci 70, 155–166 (2020). https://doi.org/10.1007/s12031-019-01399-5

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Keywords

  • SLC6A3
  • Schizophrenia
  • Meta-analysis
  • Pooled analysis