Journal of Molecular Neuroscience

, Volume 69, Issue 4, pp 628–635 | Cite as

LPP and RYR2 Gene Polymorphisms Correlate with the Risk and the Prognosis of Astrocytoma

  • Qu Chen
  • Yao Sun
  • Jiamin Wu
  • Zichao Xiong
  • Fanglin Niu
  • Tianbo JinEmail author
  • Qiujian ZhaoEmail author


Astrocytoma is the most common neuroepithelial tumor. Genetic factors play an important role in the development and prognosis of astrocytoma. So this study focuses on the impact of LPP and RYR2 genes on the occurrence and prognosis of astrocytoma. Rs12594 and rs16835904 in the RYR2 gene and rs1064607, rs3796283, and rs2378456 in the LPP gene were selected and genotyped using Agena MassARRAY in 365 patients and 379 healthy populations. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined using logistic regression to assess the influence of gene polymorphisms on occurrence of astrocytoma. The association between genotype and survival outcomes was performed by the Kaplan-Meier method, the log-rank test, and the Cox regression analysis. The survival rates of patients receiving gross total resection and postoperative chemotherapy were higher than patients receiving near total resection and subtotal resection and without chemotherapy. In recessive model, the patients with LPP rs2378456 CC genotype increased the risk of astrocytoma (OR = 1.43, 95% CI 1.01–2.02, p = 0.042). Stratified analysis shows that RYR2 rs16835904 TC-TT genotype facilitated the risk of astrocytoma in male (OR = 1.93, 95% CI 1.15–3.24, p = 0.011). Cox regression analysis shows that RYR2 rs12594 AA genotype and AG genotype were associated with OS of astrocytoma (AG genotype: HR = 1.62, 95% CI 1.04–2.53, p = 0.034; AA genotype: HR = 1.70, 95% CI 1.08–2.68, p = 0.021). RYR2 and LPP genes were found to affect the occurrence and prognosis of astrocytoma.


Astrocytoma RYR2 gene LPP gene Genetic susceptibility Prognosis 



We are grateful to all patients who participated in the study. We would also like to thank the clinicians and other hospital staff who contributed to the data collection for this study.

Author’s Contributions

QC prepared manuscript, YS collected data, JMW and ZCX analyzed data, FLN searched literature, TBJ and QJZ designed the study.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Clinical LaboratoryBaoji Central HospitalBaojiChina
  2. 2.Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of EducationNorthwest UniversityXi’anChina

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