Journal of Molecular Neuroscience

, Volume 69, Issue 4, pp 557–562 | Cite as

Association between Apolipoprotein E Gene Polymorphism and Alzheimer's Disease in an Iranian Population: A Meta-Analysis

  • Morteza Abyadeh
  • Kurosh Djafarian
  • Fatemeh Heydarinejad
  • Shahab Alizadeh
  • Sakineh Shab-BidarEmail author


The development of Alzheimer's disease (AD) has been strongly linked to the apolipoprotein E (APOE) polymorphism. A number studies have reported that the APOE ε4 allele is a genetic risk factor for developing AD, whereas the APOE ε2 and APOE ε3 alleles are considered to be neutral or even protective; however, there are conflicting data about these relationships in certain ethnic populations. Several meta-analyses have been performed to reduce the heterogeneity of results from different studies and estimate the real association in specific ethnicities. The aim of this study was to investigate the association between the APOE polymorphism and AD in an Iranian population. Our results showed a higher incidence of AD among individuals carrying the APOE ε4 allele (OR = 4.81, 95% CI: 3.28–7.05), more notably in those with the APOE ε4/e4 genotype (OR = 7.47, 95% CI: 2.35–23.73), while carrying the APOE ε3 allele was demonstrated to have a protective effect (OR = 0.40, 95% CI: 0.30–0.54). The association between the APOE ε2 allele and AD was not statically significant. However, further studies focusing on other parameters such as age, sex and environmental conditions are needed to reveal the true association between the APOE polymorphism and AD.


Apolipoprotein E Polymorphism Alzheimer’s disease Meta-analysis 



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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and TechnologyACECRTehranIran
  2. 2.Department of Clinical Nutrition, School of Nutritional Sciences and DieteticsTehran University of Medical Sciences (TUMS)TehranIran
  3. 3.Department of Nursing, School of Nursing and MidwiferyShahroud University of Medical SciencesShahroudIran
  4. 4.Department of Community Nutrition, School of Nutritional Sciences and DieteticsTehran University of Medical Sciences (TUMS)TehranIran

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