Journal of Molecular Neuroscience

, Volume 67, Issue 2, pp 305–311 | Cite as

GM1 Acupoint Injection Improves Mental Retardation in Children with Cerebral Palsy

  • Enyao LiEmail author
  • Pengju Zhao
  • Jie Jian
  • Hong Wu
  • Shuibo Gao
  • Hongyin Zhai


To study the clinical effectiveness and mechanism of GM1 acupoint injection therapy on mental retardation for children with cerebral palsy (CP). A total of 90 children with CP were divided into acupoint injection group (group A), subcutaneous injection group (group B), and control group (group C). Another 30 healthy children were set as a healthy control group (group D). The Mental Developmental Index (MDI), Psychomotor Developmental Index (PDI), and hemodynamic parameters in the cerebral arteries were measured before and after treatment. After three treatment courses, the MDI and PDI in groups A, B, and C were increased, and the increase in group A was most obvious (P < 0.05). Peak systolic velocity, mean velocity, and end-diastolic velocity were also elevated in group A, and after three treatment courses, resistance index decreased with a statistical significance (P < 0.05). However, there were no significant changes in groups B and C (P > 0.05). For all groups, neuron-specific enolase levels decreased and total superoxide dismutase increased after treatment. Acupoint injection therapy combined with conventional rehabilitation therapy demonstrated significant effects on cerebral hemodynamic conditions for children with CP.


Cerebral palsy Mental retardation Acupoint injection Rehabilitation therapy Cerebral blood flow 



This research could not be completed successfully without the careful guidance of Junfang Teng professor and strong support from our colleagues of the Fifth Affiliated Hospital of Zhengzhou University. Deep appreciation should be given to them.

Funding Information

This research was supported by the Major Project of Synergistic Innovation in Zhengzhou (Zhengzhou University, Grant No. 18XTZX12003), Special Research Project of Traditional Chinese Medicine in Henan Province (Grant No. 2018ZY3013), Henan Medical Science and Technology Tackling Project (Grant No. 2018020223), Key Scientific Research Projects of Higher Education Institutions in Henan Province (Grant No. 17A320007), and Research Project of Vocational Education Teaching Reform in Henan Province (Grant No. ZJC18051).

Compliance with Ethical Standards

The study protocol was approved by the Medical Ethics Committee of the Fifth Affiliated Hospital of Zhengzhou University, and the guardians of all participants signed the informed consent form.

Conflict of Interest

The authors declare that they have no conflicts of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Children Rehabilitation MedicineFifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina
  2. 2.LaboratoryHenan Province Hospital of Traditional China MedicineZhengzhouChina
  3. 3.Department of Children Rehabilitation MedicineThird Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

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