Journal of Molecular Neuroscience

, Volume 67, Issue 1, pp 165–171 | Cite as

HDAC9 Polymorphisms Predict Susceptibility, Severity, and Short-Term Outcome of Large Artery Atherosclerotic Stroke in Chinese Population

  • Mengmeng Wang
  • Mengmeng Gu
  • Zibao Li
  • Bo Sun
  • Xi Cheng
  • Zhengze Dai
  • Shun Li
  • Lulu Xiao
  • Min Zhao
  • Zhaojun Wang
  • Ying Lin
  • Yahong Liu
  • Jian Xu
  • Zhizhong ZhangEmail author
  • Xinfeng LiuEmail author


Recently, a genome-wide association study (GWAS) detected two histone deacetylase 9 (HDAC9) polymorphisms (rs2074633 and rs28688791) which may be associated with risk of large artery atherosclerotic (LAA) stroke. This study aimed to investigate whether these two polymorphisms were associated with susceptibility, severity, and short-term outcome of LAA stroke in a southern Chinese Han population. rs2074633 and rs28688791 were genotyped using SNPscan technology in 1011 LAA stroke patients and 1121 healthy controls. Stroke severity on admission and short-term outcome were, respectively, assessed by the National Institute of Health Stroke Scale (NIHSS) score on admission and modified Rankin Scale score at 3 months after stroke onset. rs2074633 (P = 0.039) and rs28688791 (P = 0.025) were associated with risk of LAA stroke. In subgroup analysis according to sex and age, this increased risk was only found in males (P = 0.029 for rs2074633; P = 0.013 for rs28688791) and adults aged < 60 years (P = 0.009 for rs2074633; P = 0.003 for rs28688791). Moreover, we detected significant interactions between these two polymorphisms and age (Pinteraction = 0.027 for rs2074633; Pinteraction = 0.044 for rs28688791). The CC genotype of rs28688791 (P = 0.037) was also associated with moderate and severe stroke (NIHSS ≥ 6). Additionally, the CC genotype of rs2074633 and rs28688791 (rs2074633, P = 0.019; rs28688791, P = 0.023) showed significant association with unfavorable short-term outcome of LAA stroke. Our results indicated that HDAC9 polymorphisms may be used as biomarkers for susceptibility, severity, and short-term outcome of LAA stroke.


Histone deacetylase 9 Ischemic stroke Polymorphism 


Funding Information

This study was supported by the National Natural Science Foundation of China (81771285, 81701184, 81530038, 81501019, and 81571148) and the China Postdoctoral Science Foundation (2016M592954).

Compliance with Ethical Standards

This study was approved by the Ethics Review Board of Jinling Hospital in Nanjing, China

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

12031_2018_1221_MOESM1_ESM.docx (54 kb)
ESM 1 (DOCX 53 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Neurology, Jinling HospitalMedical School of Nanjing UniversityNanjingChina
  2. 2.Department of NeurologyJinling Clinical College of Nanjing Medical UniversityNanjingChina
  3. 3.Department of NeurologyNanjing Pukou HospitalNanjingChina
  4. 4.Department of Neurology, Jinling HospitalSouthern Medical UniversityNanjingChina
  5. 5.Neurology DepartmentWayne State University/Detroit Medical CenterDetroitUSA

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