Journal of Molecular Neuroscience

, Volume 67, Issue 1, pp 72–81 | Cite as

Circular RNAs: Functions and Prospects in Glioma

  • Zheng Hao
  • Si Hu
  • Zheng Liu
  • Weixin Song
  • Yeyu Zhao
  • Meihua LiEmail author


Improving the survival rate of patients with glioma, a malignant tumor of the human brain has become increasingly important. In recent years, the function of circular RNAs (circRNAs) in different diseases and the pathophysiological mechanisms involved have been elucidated. In the pathophysiological mechanism, the primary function of circRNAs is to act as microRNA sponges. An increasing number of studies have found that circRNAs are differentially expressed in gliomas and regulate the occurrence, proliferation, and invasion of glioma and thus may be potential markers for the diagnosis of gliomas. Additionally, some circRNAs have been associated with glioma staging and may be useful in determining prognosis. Based on the stability and high conservation of circRNAs, we believe that circRNAs may have molecular targets that are useful for the treatment of glioma. In this review, we summarize the current research regarding the role of circRNAs in gliomas, discuss the potential value and role of circRNAs in gliomas, and provide new perspectives for future research.


Circular RNA MicroRNA sponge Biomarker Targeted therapy 


Funding information

This work was supported by the National Natural Science Foundation of China (NSFC): 81860225. And Jiangxi Provincial Postgraduate Innovation Fund Project (No. YC2017-S102).


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Authors and Affiliations

  1. 1.Department of NeurosurgeryThe First Affiliated Hospital of Nanchang UniversityNanchangChina

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