Hispidulin Protects Against Focal Cerebral Ischemia Reperfusion Injury in Rats
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Focal cerebral ischemia is associated with ischemia/reperfusion (I/R) injury. Hispidulin is a flavonoid compound with a variety of pharmacological properties. The neuroprotective effects of hispidulin have not been fully elucidated. Herein, we demonstrated that pretreatment of animals with hispidulin improved the neurological outcomes and decreased the infarct size and brain edema in the cerebral focal I/R model. Mechanistically, we showed in vivo and in vitro that hispidulin exerted a protective effect against I/R injury by inducing the Nrf2 antioxidant pathway through modulation of AMPK/GSK3β signaling. Taken together, our results suggest that hispidulin may be a useful neuroprotective agent against ischemia/reperfusion (I/R) injury.
KeywordsHispidulin Ischemia/reperfusion (I/R) injury Nrf2 AMPK/GSK3β
The study was supported by Shandong Province Chinese Medicine Science and Technology Development Project (2017-321) and Qingdao medical scientific research guidance program (2016-WJZD024).
Compliance with Ethical Standards
The experimental protocol was approved by the Medical Ethics Committee of The Affiliated Qingdao Hiser Hospital of Qingdao University.
Conflict of Interest
The authors declare that they have no conflict of interest.
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