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Journal of Molecular Neuroscience

, Volume 65, Issue 2, pp 127–140 | Cite as

Transcriptional Regulation Involved in Fear Memory Reconsolidation

  • Xu Wang
  • Min Li
  • Haitao Zhu
  • Yongju Yu
  • Yuanyuan Xu
  • Wenmo Zhang
  • Chen Bian
Article
  • 156 Downloads

Abstract

Memory reconsolidation has been demonstrated to offer a potential target period during which the fear memories underlying fear disorders can be disrupted. Reconsolidation is a labile stage that consolidated memories re-enter after memories are reactivated. Reactivated memories, induced by cues related to traumatic events, are susceptible to strengthening and weakening. Gene transcription regulation and protein synthesis have been suggested to be required for fear memory reconsolidation. Investigating the transcriptional regulation mechanisms underlying reconsolidation may provide a therapeutic method for the treatment of fear disorders such as post-traumatic stress disorder (PTSD). However, the therapeutic effect of treating a fear disorder through interfering with reconsolidation is still contradictory. In this review, we summarize several transcription factors that have been linked to fear memory reconsolidation and propose that transcription factors, as well as related signaling pathways can serve as targets for fear memory interventions. Then, we discuss the application of pharmacological and behavioral interventions during reconsolidation that may or not efficiently treat fear disorders.

Keywords

Fear memory Reconsolidation Transcriptional factor Post-traumatic stress disorder 

Notes

Acknowledgments

This work was supported by the National Science Foundation of China (NSFC, No. 31500896) and Natural Science Foundation Project of CQ (cstc2016jcyjA0587).

Compliance with ethical standards

Conflicts of Interest

The authors declare that they have no conflicts of interest.

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Military Psychology, College of PsychologyArmy Medical UniversityChongqingChina
  2. 2.Forth Battalion of Cadet BrigadeArmy Medical UniversityChongqingChina
  3. 3.Medical CompanyTroops 95848 of People’s Liberation ArmyXiaoganChina
  4. 4.Department of FundamentalArmy Logistical University of PLAChongqingChina

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