Journal of Molecular Neuroscience

, Volume 63, Issue 2, pp 243–253 | Cite as

Oxygen Supplementation Improves Protein Milieu Supportive of Protein Synthesis and Antioxidant Function in the Cortex of Alzheimer’s Disease Model Mice—a Quantitative Proteomic Study

  • Hao Wang
  • Xiaoyu Hong
  • Shuiming Li
  • Yong WangEmail author


Protein synthesis has been reported to be impaired in early-stage Alzheimer’s disease (AD). Previously, we found that oxygen supplementation improved cognitive function and reduced mitochondrial damage in AD model mice. In the present study, we examined the effects of supplemental oxygen treatment on protein synthesis and oxidative damage. The synthesis of numerous proteins involved in mRNA splicing, transcription regulation, and translation was found to be significantly upregulated in cortex tissues of AD model mice given a supplemental oxygen treatment (OT group), relative to those of non-treated control AD model mice (Ctrl group), suggesting that impairment in protein synthesis may be alleviated by increased oxygen inhalation. Methionine oxidation and oxidation levels in general were similar between the OT and Ctrl groups, indicating that the oxygen supplementation treatment did not cause increases in peptide oxidation levels. On the contrary, the OT group exhibited upregulation of several proteins associated with antioxidant defense. These results support further exploration into the development of supplementary oxygen treatment as a potential therapy for AD.


Alzheimer’s disease Protein synthesis Oxygen Oxidative stress Antioxidant defense Quantitative proteomics 


Funding Information

This work was supported by the Key Programs of Shenzhen (NO. JSGG20140703163838793) and the Basic Research Project of Shenzhen (NO. 20150006).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.College of Life Sciences and Oceanography, Shenzhen Key Laboratory of Microbial Genetic EngineeringShenzhen UniversityShenzhenChina
  2. 2.College of Life Sciences and Oceanography, Shenzhen Key Laboratory of Marine Bioresources and EcologyShenzhen UniversityShenzhenChina

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