Journal of Molecular Neuroscience

, Volume 56, Issue 4, pp 887–897 | Cite as

The Neural Stem Cell Microenvironment: Focusing on Axon Guidance Molecules and Myelin-Associated Factors

  • Chao-Jin XuEmail author
  • Jun-Ling Wang
  • Wei-Lin JinEmail author


Neural stem cells (NSCs) could produce various cell phenotypes in the subventricular zone (SVZ) and dentate gyrus of the hippocampus in the central nervous system (CNS), where neurogenesis has been determined to occur. The extracellular microenvironment also influences the behaviors of NSCs during development and at CNS injury sites. Our previous study indicates that myelin, a component of the CNS, could regulate the differentiation of NSCs in vitro. Recent reports have implicated three myelin-derived inhibitors, NogoA, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp), as well as several axon guidance molecules as regulators of NSC survival, proliferation, migration, and differentiation. However, the molecular mechanisms underlying the behavior of NSCs are not fully understood. In this study, we summarize the current literature on the effects of different extrinsic factors on NSCs and discuss possible mechanisms, as well as future possible clinical applications.


Neural stem cell (NSCs) Myelin Axon guidance molecules Differentiation 



The project is supported by the Zhejiang Provincial Natural Science Foundation of China (LY13H090007) and the National Natural Science Foundation of China (No. 81272801)

Conflict of interest

We declare that we did not receive financial support or maintain relationships that may pose a conflict of interest.


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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Histology and Embryology, Institute of NeuroscienceWenzhou Medical UniversityCha ShanChina
  2. 2.School of Laboratory Medicine and Life ScienceWenzhou Medical UniversityWenzhouChina
  3. 3.Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, School of Electronic Information and Electronic EngineeringShanghai Jiao Tong UniversityShanghaiChina
  4. 4.School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina

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