Journal of Molecular Neuroscience

, Volume 56, Issue 3, pp 553–561 | Cite as

Elevated Serum Homocysteine (Hcy) Levels May Contribute to the Pathogenesis of Cerebral Infarction

  • Hong-Juan Fu
  • Li-Bo Zhao
  • Ju-Jun Xue
  • Zhi-Xuan Wu
  • Yue-Ping Huang
  • Wei Liu
  • Zhan GaoEmail author


The purpose of this meta-analysis was to investigate the correlation between serum homocysteine (Hcy) levels and the pathogenesis of cerebral infarction (CI). Relevant studies involving serum Hcy levels and the pathogenesis of CI were identified using electronic database search supplemented with manual search. The search result studies were screened in accordance with our strict inclusion and exclusion criteria. Statistical analyses were conducted with Comprehensive Meta Analysis 2.0 (CMA 2.0) software. A total of 13 studies were eligible for our meta-analysis and included 1206 patients with CI and 1202 healthy controls. Our meta-analysis revealed that the serum Hcy levels in CI patients were significantly higher than those in healthy controls. Subgroup analysis based on ethnicity showed that Caucasians and Asians had significantly higher serum Hcy levels in CI patients compared to healthy controls and Africans showed no significant differences in serum Hcy levels between CI patients and controls. In conclusion, our meta-analysis reveals a strong correlation between elevated serum Hcy levels and the pathogenesis of CI, suggesting that serum Hcy levels may be an important biomarker for the early diagnosis and treatment assessment of CI.


Homocysteine Cerebral infarction Case-control study Meta-analysis Pathogenesis Serum levels Biomarker Treatment 



We would like to appreciate the reviewers for their helpful comments on this paper.

Conflict of Interest

The authors have proclaimed that there are no existing competing interests.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Hong-Juan Fu
    • 1
  • Li-Bo Zhao
    • 1
  • Ju-Jun Xue
    • 1
  • Zhi-Xuan Wu
    • 1
  • Yue-Ping Huang
    • 1
  • Wei Liu
    • 1
  • Zhan Gao
    • 1
    Email author
  1. 1.Department of Elderly NeurologyHeilongjiang Provincial HospitalHarbinPeople’s Republic of China

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