Journal of Molecular Neuroscience

, Volume 50, Issue 2, pp 360–367 | Cite as

Effect of Genetic Polymorphism +294T/C in Peroxisome Proliferator-Activated Receptor Delta on the Risk of Ischemic Stroke in a Tunisian Population

  • Khouloud Chehaibi
  • Mohamed Yahia Hrira
  • Mustapha Rouis
  • Mohamed Najah
  • Imen Jguirim-Souissi
  • Samir Nouira
  • Mohamed Naceur Slimane
Article

Abstract

PPARδ +294T/C polymorphism was investigated in diabetics, in normolipidemic healthy controls, in dyslipidemic and nondyslipidemic coronary artery disease patients but never in ischemic stroke patients. The aim of this study was to explore, for the first time, the relationship between the genetic polymorphism of PPARδ and the risk of ischemic stroke among patients with diabetes. The study group consisted of 196 patients with ischemic stroke and 192 controls. Plasma concentrations of total cholesterol, triglycerides, low-, and high-density lipoprotein did not differ significantly between subjects carrying the TT genotype and those carrying the CC/TC genotype in both ischemic stroke patients (with or without diabetes) and control groups. The +294C allele (CC + CT genotypes) as compared with TT genotypes was found to be higher in total ischemic stroke patients than in controls. On the other hand, no interaction between diabetes and PPAR +294T/C polymorphism on the risk of ischemic stroke was found (p = 0.089). The PPARδ +294T/C polymorphism was associated with the risk of ischemic stroke in Tunisian subjects. This polymorphism has no influence on plasma lipoprotein concentrations and body mass index either in healthy subjects or in ischemic stroke patients with or without diabetes both in males and females.

Keywords

PPARδ Polymorphism Diabetes Ischemic stroke 

Notes

Acknowledgments

We would like to thank Dr. Nouira Samir of the Emergency Department at Fattouma Bourguiba University Hospital in Monastir (Tunisia) for recruiting stroke patients and for his help. A part of this work was supported by a grant from “Ministère de l'Enseignement Supérieur, de la Recherche Scientifique et de la Technologie-Tunisie.”

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Khouloud Chehaibi
    • 1
  • Mohamed Yahia Hrira
    • 2
  • Mustapha Rouis
    • 3
  • Mohamed Najah
    • 1
  • Imen Jguirim-Souissi
    • 1
  • Samir Nouira
    • 4
  • Mohamed Naceur Slimane
    • 1
  1. 1.Research Unit: UR 12ES09 Dyslipidemia and Atherogenesis, Faculty of MedicineMonastirTunisia
  2. 2.ResearchUnit: UR 07/06, Faculty of PharmacyMonastirTunisia
  3. 3.UMR 7079 Physiology and PhysiopathologyUniversity Pierre and Marie CurieParis 6France
  4. 4.Emergency DepartmentCHU Fattouma BourguibaMonastirTunisia

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