Journal of Molecular Neuroscience

, Volume 53, Issue 3, pp 298–305

Cholinesterases as Biomarkers for Parasympathetic Dysfunction and Inflammation-Related Disease

  • Shani Shenhar-Tsarfaty
  • Shlomo Berliner
  • Natan M. Bornstein
  • Hermona Soreq
Article

Abstract

Accumulating evidence suggests parasympathetic dysfunction and elevated inflammation as underlying processes in multiple peripheral and neurological diseases. Acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (AChE and BChE, respectively), which are also expressed in the serum. Here, we consider the potential value of both enzymes as possible biomarkers in diseases associated with parasympathetic malfunctioning. We cover the modulations of cholinesterase activities in inflammation-related events as well as by cholinesterase-targeted microRNAs. We further discuss epigenetic control over cholinesterase gene expression and the impact of single-nucleotide polymorphisms on the corresponding physiological and pathological processes. In particular, we focus on measurements of circulation cholinesterases as a readily quantifiable readout for changes in the sympathetic/parasympathetic balance and the implications of changes in this readout in health and disease. Taken together, this cumulative know-how calls for expanding the use of cholinesterase activity measurements for both basic research and as a clinical assessment tool.

Keywords

Cholinesterases Acetylcholinesterase Butyrylcholinesterase Biomarkers Diseases Inflammation 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Shani Shenhar-Tsarfaty
    • 1
    • 2
  • Shlomo Berliner
    • 3
  • Natan M. Bornstein
    • 4
  • Hermona Soreq
    • 1
  1. 1.The Edmond and Lily Safra Center for Brain Science and Department of Biological Chemistry, The Life Sciences InstituteThe Hebrew University of JerusalemJerusalemIsrael
  2. 2.Internal Medicine “E” and Neurology Departments, Tel Aviv Medical Center, affiliated to the Sackler School of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Internal Medicine “E” Department, Tel Aviv Medical Center, affiliated to the Sackler School of MedicineTel Aviv UniversityTel AvivIsrael
  4. 4.Neurology Department, Tel Aviv Medical Center, affiliated to the Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

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