Journal of Molecular Neuroscience

, Volume 49, Issue 1, pp 140–149 | Cite as

Formaldehyde Impairs Learning and Memory Involving the Disturbance of Hydrogen Sulfide Generation in the Hippocampus of Rats

  • Xiao-Qing Tang
  • Yuan-Yuan Zhuang
  • Ping Zhang
  • Heng-Rong Fang
  • Cheng-Fang Zhou
  • Hong-Feng Gu
  • Hui Zhang
  • Chun-Yan Wang
Article

Abstract

Formaldehyde (FA), a well-known indoor and outdoor pollutant, has been implicated as the responsible agent in the development of neurocognitive disorders. Hydrogen sulfide (H2S), the third gasotransimitter, is an endogenous neuromodulator, which facilitates the induction of hippocampal long-term potentiation, involving the functions of learning and memory. In the present study, we analyzed the effects of intracerebroventricular injection of FA on the formation of learning and memory and the generation of endogenous H2S in the hippocampus of rats. We found that the intracerebroventricular injection of FA in rats impairs the function of learning and memory in the Morris water maze and novel object recognition test and increases the formation of apoptosis and lipid peroxidation in the hippocampus. We also showed that FA exposure inhibits the expression of cystathionine β-synthase, the major enzyme responsible for endogenous H2S generation in hippocampus and decreases the production of endogenous H2S in hippocampus in rats. These results suggested that FA-disturbed generation of endogenous H2S in hippocampus leads to the oxidative stress-mediated neuron damage, ultimately impairing the function of learning and memory. Our findings imply that the disturbance of endogenous H2S generation in hippocampus is a potential contributing mechanism underling FA-caused learning and memory impairment.

Keywords

Formaldehyde Hydrogen sulfide Learning and memory Morris water maze Novel object recognition test 

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Xiao-Qing Tang
    • 1
    • 2
  • Yuan-Yuan Zhuang
    • 2
    • 3
  • Ping Zhang
    • 4
  • Heng-Rong Fang
    • 1
    • 2
  • Cheng-Fang Zhou
    • 1
    • 2
  • Hong-Feng Gu
    • 1
    • 2
  • Hui Zhang
    • 5
  • Chun-Yan Wang
    • 2
  1. 1.Department of Physiology, Medical CollegeUniversity of South ChinaHengyangPeople’s Republic of China
  2. 2.Institute of Cognition and Nervous Systems Disease, Medical CollegeUniversity of South ChinaHengyangPeople’s Republic of China
  3. 3.Division of Science and Technology ResearchKingmed Diagnostics CenterGuangzhouPeople’s Republic of China
  4. 4.Department of Neurology, Nanhua Affiliated HospitalUniversity of South ChinaHengyangPeople’s Republic of China
  5. 5.Hospital of OrthopedicsGeneral Hospital of Guangzhou Military Command of PLAGuangzhouPeople’s Republic of China

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