Journal of Molecular Neuroscience

, Volume 48, Issue 3, pp 654–659 | Cite as

Role of Neurotrophins in the Development and Function of Neural Circuits That Regulate Energy Homeostasis

  • Samira Fargali
  • Masato Sadahiro
  • Cheng Jiang
  • Amy L. Frick
  • Tricia Indall
  • Valeria Cogliani
  • Jelle Welagen
  • Wei-Jye Lin
  • Stephen R. Salton
Article

Abstract

Members of the neurotrophin family, including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5, and other neurotrophic growth factors such as ciliary neurotrophic factor and artemin, regulate peripheral and central nervous system development and function. A subset of the neurotrophin-dependent pathways in the hypothalamus, brainstem, and spinal cord, and those that project via the sympathetic nervous system to peripheral metabolic tissues including brown and white adipose tissue, muscle and liver, regulate feeding, energy storage, and energy expenditure. We briefly review the role that neurotrophic growth factors play in energy balance, as regulators of neuronal survival and differentiation, neurogenesis, and circuit formation and function, and as inducers of critical gene products that control energy homeostasis.

Keywords

Brain-derived neurotrophic factor (BDNF) Corticotropin-releasing hormone (CRH) Hypothalamus Nerve growth factor (NGF) Neurotrophin VGF 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Samira Fargali
    • 1
  • Masato Sadahiro
    • 1
  • Cheng Jiang
    • 1
  • Amy L. Frick
    • 1
  • Tricia Indall
    • 1
  • Valeria Cogliani
    • 1
  • Jelle Welagen
    • 1
  • Wei-Jye Lin
    • 1
  • Stephen R. Salton
    • 1
    • 2
    • 3
    • 4
  1. 1.Fishberg Department of NeuroscienceMount Sinai School of MedicineNew YorkUSA
  2. 2.Brookdale Department of Geriatrics and Palliative MedicineMount Sinai School of MedicineNew YorkUSA
  3. 3.Friedman Brain InstituteMount Sinai School of MedicineNew YorkUSA
  4. 4.Department of NeuroscienceMount Sinai School of MedicineNew YorkUSA

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