An AD-Related Neuroprotector Rescues Transformed Rat Retinal Ganglion Cells from CoCl2-Induced Apoptosis
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Some ocular diseases characterized by apoptotic death of retinal ganglion cells (RGCs) and Alzheimer’s disease (AD) are chronic neurodegenerative disorders and have similarities in neuropathology. Humanin (HN) is known for its ability to suppress neuronal death induced by AD-related insults. In present study, we investigated the neuroprotective effects of HN on hypoxia-induced toxicity in RGC-5 cells. Hypoxia mimetic compound cobalt chloride (CoCl2) could increase the cell viability loss and apoptosis, whereas HN can significantly attenuate these effects. This finding may provide new therapeutics for the retinal neurodegenerative diseases targeting neuroprotection.
KeywordsHumanin Apoptosis RGC-5 cells Hypoxia
We thank Professors Jianing Miao and Peng Ding, from the Laboratory of Shengjing Hospital, China Medical University, China, for their technical assistance.
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